PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma

Inositol polyphosphate 5-phosphatases can terminate downstream signalling of phosphatidylinositol-3 kinase; however, their biological role in the pathogenesis of cancer is controversial. Here we report that the inositol polyphosphate 5-phosphatase, phosphatidylinositol 4,5-bisphosphate 5-phosphatase...

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Detalles Bibliográficos
Autores principales: Ye, Yan, Jin, Lei, Wilmott, James S., Hu, Wang Lai, Yosufi, Benafsha, Thorne, Rick F., Liu, Tao, Rizos, Helen, Yan, Xu Guang, Dong, Li, Tay, Kwang Hong, Tseng, Hsin-Yi, Guo, Su Tang, de Bock, Charles E., Jiang, Chen Chen, Wang, Chun Yan, Wu, Mian, Zhang, Lin Jie, Hersey, Peter, Scolyer, Richard A., Zhang, Xu Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586716/
https://www.ncbi.nlm.nih.gov/pubmed/23443536
http://dx.doi.org/10.1038/ncomms2489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586716/
https://www.ncbi.nlm.nih.gov/pubmed/23443536
http://dx.doi.org/10.1038/ncomms2489

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