GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance

Efficient engulfment of apoptotic cells is critical for maintaining tissue homoeostasis. When phagocytes recognize ‘eat me’ signals presented on the surface of apoptotic cells, this subsequently induces cytoskeletal rearrangement of phagocytes for the engulfment through Rac1 activation. However, the...

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Detalles Bibliográficos
Autores principales: Nakaya, Michio, Tajima, Mitsuru, Kosako, Hidetaka, Nakaya, Takeo, Hashimoto, Akiko, Watari, Kenji, Nishihara, Hiroaki, Ohba, Mina, Komiya, Shiori, Tani, Naoki, Nishida, Motohiro, Taniguchi, Hisaaki, Sato, Yoji, Matsumoto, Mitsuru, Tsuda, Makoto, Kuroda, Masahiko, Inoue, Kazuhide, Kurose, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586722/
https://www.ncbi.nlm.nih.gov/pubmed/23443560
http://dx.doi.org/10.1038/ncomms2540

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