Cargando…
Disease mutations in the ryanodine receptor N-terminal region couple to a mobile intersubunit interface
Ryanodine receptors are large channels that release Ca(2+) from the endoplasmic and sarcoplasmic reticulum. Hundreds of RyR mutations can cause cardiac and skeletal muscle disorders, yet detailed mechanisms explaining their effects have been lacking. Here we compare pseudo-atomic models and propose...
Autores principales: | Kimlicka, Lynn, Lau, Kelvin, Tung, Ching-Chieh, Van Petegem, Filip |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586727/ https://www.ncbi.nlm.nih.gov/pubmed/23422674 http://dx.doi.org/10.1038/ncomms2501 |
Ejemplares similares
-
Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screening
por: Zhang, Jingyan, et al.
Publicado: (2021) -
The functional significance of redox-mediated intersubunit cross-linking in regulation of human type 2 ryanodine receptor
por: Nikolaienko, Roman, et al.
Publicado: (2020) -
RyR2 disease mutations at the C-terminal domain intersubunit interface alter closed-state stability and channel activation
por: Guo, Wenting, et al.
Publicado: (2021) -
The structural arrangement at intersubunit interfaces in homomeric kainate receptors
por: Litwin, Douglas B., et al.
Publicado: (2019) -
Interrogation of the intersubunit interface of the open Hv1 proton channel with a probe of allosteric coupling
por: Hong, Liang, et al.
Publicado: (2015)