Potent Inhibition of HIV-1 Reverse Transcriptase and Replication by Nonpseudoknot, “UCAA-motif” RNA Aptamers

RNA aptamers that bind the reverse transcriptase (RT) of human immunodeficiency virus (HIV) compete with nucleic acid primer/template for access to RT, inhibit RT enzymatic activity in vitro, and suppress viral replication when expressed in human cells. Numerous pseudoknot aptamers have been identif...

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Detalles Bibliográficos
Autores principales: Whatley, Angela S, Ditzler, Mark A, Lange, Margaret J, Biondi, Elisa, Sawyer, Andrew W, Chang, Jonathan L, Franken, Joshua D, Burke, Donald H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586799/
https://www.ncbi.nlm.nih.gov/pubmed/23385524
http://dx.doi.org/10.1038/mtna.2012.62

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586799/
https://www.ncbi.nlm.nih.gov/pubmed/23385524
http://dx.doi.org/10.1038/mtna.2012.62

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