Focal Delivery of AAV2/1-transgenes Into the Rat Brain by Localized Ultrasound-induced BBB Opening

Delivery of drugs and macromolecules to the central nervous system (CNS) is hindered by the blood–brain barrier (BBB). Several approaches have been used to overcome this hindrance to facilitate the treatment of various CNS diseases. We now present results showing that chimeric adeno-associated virus...

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Detalles Bibliográficos
Autores principales: Alonso, Angelika, Reinz, Eileen, Leuchs, Barbara, Kleinschmidt, Jürgen, Fatar, Marc, Geers, Bart, Lentacker, Ine, Hennerici, Michael G., de Smedt, Stefaan C., Meairs, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Methods - Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586801/
https://www.ncbi.nlm.nih.gov/pubmed/23423361
http://dx.doi.org/10.1038/mtna.2012.64

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