Cargando…
The Effects of Supplemental Zinc and Honey on Wound Healing in Rats
OBJECTIVE(S): Clinicians have long been searching for ways to obtain "super normal" wound healing. Zinc supplementation improves the healing of open wounds. Honey can improve the wound healing with its antibacterial properties. Giving supplemental zinc to normal rats can increase the wound...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mashhad University of Medical Sciences
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586837/ https://www.ncbi.nlm.nih.gov/pubmed/23493488 |
_version_ | 1782261354890002432 |
---|---|
author | Sazegar, Ghasem Seyed Reza, Attarzadeh Hosseini Behravan, Effat |
author_facet | Sazegar, Ghasem Seyed Reza, Attarzadeh Hosseini Behravan, Effat |
author_sort | Sazegar, Ghasem |
collection | PubMed |
description | OBJECTIVE(S): Clinicians have long been searching for ways to obtain "super normal" wound healing. Zinc supplementation improves the healing of open wounds. Honey can improve the wound healing with its antibacterial properties. Giving supplemental zinc to normal rats can increase the wound tensile strength. This work is to study the concurrent effects of zinc and honey in wound healing of normal rats. MATERIALS AND METHODS: One hundred and seventy two young rats were randomly divided into four groups: control, zinc-supplement, applied honey, zinc-supplement and applied honey. Two areas of skin about 4 cm² were excised. The wound area was measured every 2 days. After 3 weeks, all animals were killed and tensile strength of wounds, zinc concentration of blood and histological improvement of wounds were evaluated. The results were analyzed using two-way ANOVA and the mean differences were tested. RESULTS: It was found that honey could inhibit the bacterial growth in skin excisions. The tensile strength was increased significantly in the second to fourth groups at 21st day (P< 0.001). Also there was a significant increase in tensile strength at the same time in the fourth group. The results of the histological study showed a considerable increase in the collagen fibers, re-epithelialization and re-vascularization in the second to fourth groups. CONCLUSION: The results of the present study indicate that zinc sulfate could retard re-epithelialization, but when used with natural honey (administered topically) it could have influent wound healing in non-zinc-deficient subjects as well. |
format | Online Article Text |
id | pubmed-3586837 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Mashhad University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-35868372013-03-14 The Effects of Supplemental Zinc and Honey on Wound Healing in Rats Sazegar, Ghasem Seyed Reza, Attarzadeh Hosseini Behravan, Effat Iran J Basic Med Sci Original Article OBJECTIVE(S): Clinicians have long been searching for ways to obtain "super normal" wound healing. Zinc supplementation improves the healing of open wounds. Honey can improve the wound healing with its antibacterial properties. Giving supplemental zinc to normal rats can increase the wound tensile strength. This work is to study the concurrent effects of zinc and honey in wound healing of normal rats. MATERIALS AND METHODS: One hundred and seventy two young rats were randomly divided into four groups: control, zinc-supplement, applied honey, zinc-supplement and applied honey. Two areas of skin about 4 cm² were excised. The wound area was measured every 2 days. After 3 weeks, all animals were killed and tensile strength of wounds, zinc concentration of blood and histological improvement of wounds were evaluated. The results were analyzed using two-way ANOVA and the mean differences were tested. RESULTS: It was found that honey could inhibit the bacterial growth in skin excisions. The tensile strength was increased significantly in the second to fourth groups at 21st day (P< 0.001). Also there was a significant increase in tensile strength at the same time in the fourth group. The results of the histological study showed a considerable increase in the collagen fibers, re-epithelialization and re-vascularization in the second to fourth groups. CONCLUSION: The results of the present study indicate that zinc sulfate could retard re-epithelialization, but when used with natural honey (administered topically) it could have influent wound healing in non-zinc-deficient subjects as well. Mashhad University of Medical Sciences 2011 /pmc/articles/PMC3586837/ /pubmed/23493488 Text en © 2011: Iranian Journal of Basic Medical Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Sazegar, Ghasem Seyed Reza, Attarzadeh Hosseini Behravan, Effat The Effects of Supplemental Zinc and Honey on Wound Healing in Rats |
title | The Effects of Supplemental Zinc and Honey on Wound Healing in Rats |
title_full | The Effects of Supplemental Zinc and Honey on Wound Healing in Rats |
title_fullStr | The Effects of Supplemental Zinc and Honey on Wound Healing in Rats |
title_full_unstemmed | The Effects of Supplemental Zinc and Honey on Wound Healing in Rats |
title_short | The Effects of Supplemental Zinc and Honey on Wound Healing in Rats |
title_sort | effects of supplemental zinc and honey on wound healing in rats |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586837/ https://www.ncbi.nlm.nih.gov/pubmed/23493488 |
work_keys_str_mv | AT sazegarghasem theeffectsofsupplementalzincandhoneyonwoundhealinginrats AT seyedrezaattarzadehhosseini theeffectsofsupplementalzincandhoneyonwoundhealinginrats AT behravaneffat theeffectsofsupplementalzincandhoneyonwoundhealinginrats AT sazegarghasem effectsofsupplementalzincandhoneyonwoundhealinginrats AT seyedrezaattarzadehhosseini effectsofsupplementalzincandhoneyonwoundhealinginrats AT behravaneffat effectsofsupplementalzincandhoneyonwoundhealinginrats |