In Cellulo Examination of a Beta-Alpha Hybrid Construct of Beta-Hexosaminidase A Subunits, Reported to Interact with the GM2 Activator Protein and Hydrolyze GM2 Ganglioside

The hydrolysis in lysosomes of GM2 ganglioside to GM3 ganglioside requires the correct synthesis, intracellular assembly and transport of three separate gene products; i.e., the alpha and beta subunits of heterodimeric beta-hexosaminidase A, E.C. # 3.2.1.52 (encoded by the HEXA and HEXB genes, respe...

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Detalles Bibliográficos
Autores principales: Sinici, Incilay, Yonekawa, Sayuri, Tkachyova, Ilona, Gray, Steven J., Samulski, R. Jude, Wakarchuk, Warren, Mark, Brian L., Mahuran, Don J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587417/
https://www.ncbi.nlm.nih.gov/pubmed/23483939
http://dx.doi.org/10.1371/journal.pone.0057908

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