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A Kinome Screen Identifies Checkpoint Kinase 1 (CHK1) as a Sensitizer for RRM1-Dependent Gemcitabine Efficacy

Gemcitabine is among the most efficacious and widely used antimetabolite agents. Its molecular targets are ribonucleotide reductase M1 (RRM1) and elongating DNA. Acquired and de novo resistance as a result of RRM1 overexpression are major obstacles to therapeutic efficacy. We deployed a synthetic le...

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Detalles Bibliográficos
Autores principales:	Zhou, Jun, Chen, Zhengming, Malysa, Agnes, Li, Xin, Oliveira, Paula, Zhang, Yingtao, Bepler, Gerold
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587420/ https://www.ncbi.nlm.nih.gov/pubmed/23483975 http://dx.doi.org/10.1371/journal.pone.0058091

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