Native Tertiary Structure and Nucleoside Modifications Suppress tRNA’s Intrinsic Ability to Activate the Innate Immune Sensor PKR

Interferon inducible protein kinase PKR is an essential component of innate immunity. It is activated by long stretches of dsRNA and provides the first line of host defense against pathogens by inhibiting translation initiation in the infected cell. Many cellular and viral transcripts contain nucleo...

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Detalles Bibliográficos
Autores principales: Nallagatla, Subba Rao, Jones, Christie N., Ghosh, Saikat Kumar B., Sharma, Suresh D., Cameron, Craig E., Spremulli, Linda L., Bevilacqua, Philip C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587421/
https://www.ncbi.nlm.nih.gov/pubmed/23483938
http://dx.doi.org/10.1371/journal.pone.0057905

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