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The Ultra-Potent and Selective TLR8 Agonist VTX-294 Activates Human Newborn and Adult Leukocytes
BACKGROUND: Newborns display distinct immune responses that contribute to susceptibility to infection and reduced vaccine responses. Toll-like receptor (TLR) agonists may serve as vaccine adjuvants, when given individually or in combination, but responses of neonatal leukocytes to many TLR agonists...
Autores principales: | Dowling, David J., Tan, Zhen, Prokopowicz, Zofia M., Palmer, Christine D., Matthews, Maura-Ann H., Dietsch, Gregory N., Hershberg, Robert M., Levy, Ofer |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587566/ https://www.ncbi.nlm.nih.gov/pubmed/23483986 http://dx.doi.org/10.1371/journal.pone.0058164 |
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