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Exposure to a Low Pathogenic A/H7N2 Virus in Chickens Protects against Highly Pathogenic A/H7N1 Virus but Not against Subsequent Infection with A/H5N1

Recent evidences have demonstrated that the presence of low pathogenic avian influenza viruses (LPAIV) may play an important role in host ecology and transmission of avian influenza viruses (AIV). While some authors have clearly demonstrated that LPAIV can mutate to render highly pathogenic avian in...

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Autores principales: Vergara-Alert, Júlia, Moreno, Ana, Zabala, Juliana G., Bertran, Kateri, Costa, Taiana P., Cordón, Iván, Rivas, Raquel, Majó, Natàlia, Busquets, Núria, Cordioli, Paolo, Rodriguez, Fernando, Darji, Ayub
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587606/
https://www.ncbi.nlm.nih.gov/pubmed/23469288
http://dx.doi.org/10.1371/journal.pone.0058692
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author Vergara-Alert, Júlia
Moreno, Ana
Zabala, Juliana G.
Bertran, Kateri
Costa, Taiana P.
Cordón, Iván
Rivas, Raquel
Majó, Natàlia
Busquets, Núria
Cordioli, Paolo
Rodriguez, Fernando
Darji, Ayub
author_facet Vergara-Alert, Júlia
Moreno, Ana
Zabala, Juliana G.
Bertran, Kateri
Costa, Taiana P.
Cordón, Iván
Rivas, Raquel
Majó, Natàlia
Busquets, Núria
Cordioli, Paolo
Rodriguez, Fernando
Darji, Ayub
author_sort Vergara-Alert, Júlia
collection PubMed
description Recent evidences have demonstrated that the presence of low pathogenic avian influenza viruses (LPAIV) may play an important role in host ecology and transmission of avian influenza viruses (AIV). While some authors have clearly demonstrated that LPAIV can mutate to render highly pathogenic avian influenza viruses (HPAIV), others have shown that their presence could provide the host with enough immunological memory to resist re-infections with HPAIV. In order to experimentally study the role of pre-existing host immunity, chickens previously infected with H7N2 LPAIV were subsequently challenged with H7N1 HPAIV. Pre-infection of chickens with H7N2 LAPIV conferred protection against the lethal challenge with H7N1 HPAIV, dramatically reducing the viral shedding, the clinical signs and the pathological outcome. Correlating with the protection afforded, sera from chickens primed with H7N2 LPAIV reacted with the H7-AIV subtype in hemagglutination inhibition assay and specifically with the N2-neuraminidase antigen. Conversely, subsequent exposure to H5N1 HPAIV resulted in a two days-delay on the onset of disease but all chickens died by 7 days post-challenge. Lack of protection correlated with the absence of H5-hemagglutining inhibitory antibodies prior to H5N1 HPAIV challenge. Our data suggest that in naturally occurring outbreaks of HPAIV, birds with pre-existing immunity to LPAIV could survive lethal infections with HA-homologous HPAIV but not subsequent re-infections with HA-heterologous HPAIV. These results could be useful to better understand the dynamics of AIV in chickens and might help in future vaccine formulations.
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spelling pubmed-35876062013-03-06 Exposure to a Low Pathogenic A/H7N2 Virus in Chickens Protects against Highly Pathogenic A/H7N1 Virus but Not against Subsequent Infection with A/H5N1 Vergara-Alert, Júlia Moreno, Ana Zabala, Juliana G. Bertran, Kateri Costa, Taiana P. Cordón, Iván Rivas, Raquel Majó, Natàlia Busquets, Núria Cordioli, Paolo Rodriguez, Fernando Darji, Ayub PLoS One Research Article Recent evidences have demonstrated that the presence of low pathogenic avian influenza viruses (LPAIV) may play an important role in host ecology and transmission of avian influenza viruses (AIV). While some authors have clearly demonstrated that LPAIV can mutate to render highly pathogenic avian influenza viruses (HPAIV), others have shown that their presence could provide the host with enough immunological memory to resist re-infections with HPAIV. In order to experimentally study the role of pre-existing host immunity, chickens previously infected with H7N2 LPAIV were subsequently challenged with H7N1 HPAIV. Pre-infection of chickens with H7N2 LAPIV conferred protection against the lethal challenge with H7N1 HPAIV, dramatically reducing the viral shedding, the clinical signs and the pathological outcome. Correlating with the protection afforded, sera from chickens primed with H7N2 LPAIV reacted with the H7-AIV subtype in hemagglutination inhibition assay and specifically with the N2-neuraminidase antigen. Conversely, subsequent exposure to H5N1 HPAIV resulted in a two days-delay on the onset of disease but all chickens died by 7 days post-challenge. Lack of protection correlated with the absence of H5-hemagglutining inhibitory antibodies prior to H5N1 HPAIV challenge. Our data suggest that in naturally occurring outbreaks of HPAIV, birds with pre-existing immunity to LPAIV could survive lethal infections with HA-homologous HPAIV but not subsequent re-infections with HA-heterologous HPAIV. These results could be useful to better understand the dynamics of AIV in chickens and might help in future vaccine formulations. Public Library of Science 2013-03-04 /pmc/articles/PMC3587606/ /pubmed/23469288 http://dx.doi.org/10.1371/journal.pone.0058692 Text en © 2013 Vergara-Alert et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Vergara-Alert, Júlia
Moreno, Ana
Zabala, Juliana G.
Bertran, Kateri
Costa, Taiana P.
Cordón, Iván
Rivas, Raquel
Majó, Natàlia
Busquets, Núria
Cordioli, Paolo
Rodriguez, Fernando
Darji, Ayub
Exposure to a Low Pathogenic A/H7N2 Virus in Chickens Protects against Highly Pathogenic A/H7N1 Virus but Not against Subsequent Infection with A/H5N1
title Exposure to a Low Pathogenic A/H7N2 Virus in Chickens Protects against Highly Pathogenic A/H7N1 Virus but Not against Subsequent Infection with A/H5N1
title_full Exposure to a Low Pathogenic A/H7N2 Virus in Chickens Protects against Highly Pathogenic A/H7N1 Virus but Not against Subsequent Infection with A/H5N1
title_fullStr Exposure to a Low Pathogenic A/H7N2 Virus in Chickens Protects against Highly Pathogenic A/H7N1 Virus but Not against Subsequent Infection with A/H5N1
title_full_unstemmed Exposure to a Low Pathogenic A/H7N2 Virus in Chickens Protects against Highly Pathogenic A/H7N1 Virus but Not against Subsequent Infection with A/H5N1
title_short Exposure to a Low Pathogenic A/H7N2 Virus in Chickens Protects against Highly Pathogenic A/H7N1 Virus but Not against Subsequent Infection with A/H5N1
title_sort exposure to a low pathogenic a/h7n2 virus in chickens protects against highly pathogenic a/h7n1 virus but not against subsequent infection with a/h5n1
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587606/
https://www.ncbi.nlm.nih.gov/pubmed/23469288
http://dx.doi.org/10.1371/journal.pone.0058692
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