β-Arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology

Alzheimer's disease (AD) is a progressive and complex neurodegenerative disease in which the γ-secretase-mediated amyloid-β (Aβ) pathology plays an important role. We found that a multifunctional protein, β-arrestin1, facilitated the formation of NCT/APH-1 (anterior pharynx-defective phenotype...

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Detalles Bibliográficos
Autores principales: Liu, Xiaosong, Zhao, Xiaohui, Zeng, Xianglu, Bossers, Koen, Swaab, Dick F, Zhao, Jian, Pei, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587707/
https://www.ncbi.nlm.nih.gov/pubmed/23208420
http://dx.doi.org/10.1038/cr.2012.167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587707/
https://www.ncbi.nlm.nih.gov/pubmed/23208420
http://dx.doi.org/10.1038/cr.2012.167

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