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Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing

Human ribosome production is up-regulated during tumorogenesis and is defective in many genetic diseases (ribosomopathies). We have undertaken a detailed analysis of human precursor ribosomal RNA (pre-rRNA) processing because surprisingly little is known about this important pathway. Processing in i...

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Detalles Bibliográficos
Autores principales:	Sloan, Katherine E., Mattijssen, Sandy, Lebaron, Simon, Tollervey, David, Pruijn, Ger J.M., Watkins, Nicholas J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587827/ https://www.ncbi.nlm.nih.gov/pubmed/23439679 http://dx.doi.org/10.1083/jcb.201207131

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