Lamin B1 fluctuations have differential effects on cellular proliferation and senescence

The nuclear lamina consists of A- and B-type lamins. Mutations in LMNA cause many human diseases, including progeria, a premature aging syndrome, whereas LMNB1 duplication causes adult-onset autosomal dominant leukodystrophy (ADLD). LMNB1 is reduced in cells from progeria patients, but the significa...

Descripción completa

Detalles Bibliográficos
Autores principales: Dreesen, Oliver, Chojnowski, Alexandre, Ong, Peh Fern, Zhao, Tian Yun, Common, John E., Lunny, Declan, Lane, E. Birgitte, Lee, Shu Jin, Vardy, Leah A., Stewart, Colin L., Colman, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587829/
https://www.ncbi.nlm.nih.gov/pubmed/23439683
http://dx.doi.org/10.1083/jcb.201206121

Ejemplares similares

Ejemplares similares