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Melatonin Anticancer Effects: Review

Melatonin (N-acetyl-5-methoxytryptamine, MLT), the main hormone produced by the pineal gland, not only regulates circadian rhythm, but also has antioxidant, anti-ageing and immunomodulatory properties. MLT plays an important role in blood composition, medullary dynamics, platelet genesis, vessel end...

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Autores principales: Di Bella, Giuseppe, Mascia, Fabrizio, Gualano, Luciano, Di Bella, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587994/
https://www.ncbi.nlm.nih.gov/pubmed/23348932
http://dx.doi.org/10.3390/ijms14022410
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author Di Bella, Giuseppe
Mascia, Fabrizio
Gualano, Luciano
Di Bella, Luigi
author_facet Di Bella, Giuseppe
Mascia, Fabrizio
Gualano, Luciano
Di Bella, Luigi
author_sort Di Bella, Giuseppe
collection PubMed
description Melatonin (N-acetyl-5-methoxytryptamine, MLT), the main hormone produced by the pineal gland, not only regulates circadian rhythm, but also has antioxidant, anti-ageing and immunomodulatory properties. MLT plays an important role in blood composition, medullary dynamics, platelet genesis, vessel endothelia, and in platelet aggregation, leukocyte formula regulation and hemoglobin synthesis. Its significant atoxic, apoptotic, oncostatic, angiogenetic, differentiating and antiproliferative properties against all solid and liquid tumors have also been documented. Thanks, in fact, to its considerable functional versatility, MLT can exert both direct and indirect anticancer effects in factorial synergy with other differentiating, antiproliferative, immunomodulating and trophic molecules that form part of the anticancer treatment formulated by Luigi Di Bella (Di Bella Method, DBM: somatostatin, retinoids, ascorbic acid, vitamin D3, prolactin inhibitors, chondroitin-sulfate). The interaction between MLT and the DBM molecules counters the multiple processes that characterize the neoplastic phenotype (induction, promotion, progression and/or dissemination, tumoral mutation). All these particular characteristics suggest the use of MLT in oncological diseases.
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spelling pubmed-35879942013-03-13 Melatonin Anticancer Effects: Review Di Bella, Giuseppe Mascia, Fabrizio Gualano, Luciano Di Bella, Luigi Int J Mol Sci Review Melatonin (N-acetyl-5-methoxytryptamine, MLT), the main hormone produced by the pineal gland, not only regulates circadian rhythm, but also has antioxidant, anti-ageing and immunomodulatory properties. MLT plays an important role in blood composition, medullary dynamics, platelet genesis, vessel endothelia, and in platelet aggregation, leukocyte formula regulation and hemoglobin synthesis. Its significant atoxic, apoptotic, oncostatic, angiogenetic, differentiating and antiproliferative properties against all solid and liquid tumors have also been documented. Thanks, in fact, to its considerable functional versatility, MLT can exert both direct and indirect anticancer effects in factorial synergy with other differentiating, antiproliferative, immunomodulating and trophic molecules that form part of the anticancer treatment formulated by Luigi Di Bella (Di Bella Method, DBM: somatostatin, retinoids, ascorbic acid, vitamin D3, prolactin inhibitors, chondroitin-sulfate). The interaction between MLT and the DBM molecules counters the multiple processes that characterize the neoplastic phenotype (induction, promotion, progression and/or dissemination, tumoral mutation). All these particular characteristics suggest the use of MLT in oncological diseases. MDPI 2013-01-24 /pmc/articles/PMC3587994/ /pubmed/23348932 http://dx.doi.org/10.3390/ijms14022410 Text en © 2013 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Di Bella, Giuseppe
Mascia, Fabrizio
Gualano, Luciano
Di Bella, Luigi
Melatonin Anticancer Effects: Review
title Melatonin Anticancer Effects: Review
title_full Melatonin Anticancer Effects: Review
title_fullStr Melatonin Anticancer Effects: Review
title_full_unstemmed Melatonin Anticancer Effects: Review
title_short Melatonin Anticancer Effects: Review
title_sort melatonin anticancer effects: review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587994/
https://www.ncbi.nlm.nih.gov/pubmed/23348932
http://dx.doi.org/10.3390/ijms14022410
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