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Nature’s Timepiece—Molecular Coordination of Metabolism and Its Impact on Aging

Circadian rhythms are found in almost all organisms from cyanobacteria to humans, where most behavioral and physiological processes occur over a period of approximately 24 h in tandem with the day/night cycles. In general, these rhythmic processes are under regulation of circadian clocks. The role o...

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Detalles Bibliográficos
Autores principales: Bednářová, Andrea, Kodrík, Dalibor, Krishnan, Natraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588029/
https://www.ncbi.nlm.nih.gov/pubmed/23434656
http://dx.doi.org/10.3390/ijms14023026
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author Bednářová, Andrea
Kodrík, Dalibor
Krishnan, Natraj
author_facet Bednářová, Andrea
Kodrík, Dalibor
Krishnan, Natraj
author_sort Bednářová, Andrea
collection PubMed
description Circadian rhythms are found in almost all organisms from cyanobacteria to humans, where most behavioral and physiological processes occur over a period of approximately 24 h in tandem with the day/night cycles. In general, these rhythmic processes are under regulation of circadian clocks. The role of circadian clocks in regulating metabolism and consequently cellular and metabolic homeostasis is an intensively investigated area of research. However, the links between circadian clocks and aging are correlative and only recently being investigated. A physiological decline in most processes is associated with advancing age, and occurs at the onset of maturity and in some instances is the result of accumulation of cellular damage beyond a critical level. A fully functional circadian clock would be vital to timing events in general metabolism, thus contributing to metabolic health and to ensure an increased “health-span” during the process of aging. Here, we present recent evidence of links between clocks, cellular metabolism, aging and oxidative stress (one of the causative factors of aging). In the light of these data, we arrive at conceptual generalizations of this relationship across the spectrum of model organisms from fruit flies to mammals.
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spelling pubmed-35880292013-03-13 Nature’s Timepiece—Molecular Coordination of Metabolism and Its Impact on Aging Bednářová, Andrea Kodrík, Dalibor Krishnan, Natraj Int J Mol Sci Review Circadian rhythms are found in almost all organisms from cyanobacteria to humans, where most behavioral and physiological processes occur over a period of approximately 24 h in tandem with the day/night cycles. In general, these rhythmic processes are under regulation of circadian clocks. The role of circadian clocks in regulating metabolism and consequently cellular and metabolic homeostasis is an intensively investigated area of research. However, the links between circadian clocks and aging are correlative and only recently being investigated. A physiological decline in most processes is associated with advancing age, and occurs at the onset of maturity and in some instances is the result of accumulation of cellular damage beyond a critical level. A fully functional circadian clock would be vital to timing events in general metabolism, thus contributing to metabolic health and to ensure an increased “health-span” during the process of aging. Here, we present recent evidence of links between clocks, cellular metabolism, aging and oxidative stress (one of the causative factors of aging). In the light of these data, we arrive at conceptual generalizations of this relationship across the spectrum of model organisms from fruit flies to mammals. MDPI 2013-01-31 /pmc/articles/PMC3588029/ /pubmed/23434656 http://dx.doi.org/10.3390/ijms14023026 Text en © 2013 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Bednářová, Andrea
Kodrík, Dalibor
Krishnan, Natraj
Nature’s Timepiece—Molecular Coordination of Metabolism and Its Impact on Aging
title Nature’s Timepiece—Molecular Coordination of Metabolism and Its Impact on Aging
title_full Nature’s Timepiece—Molecular Coordination of Metabolism and Its Impact on Aging
title_fullStr Nature’s Timepiece—Molecular Coordination of Metabolism and Its Impact on Aging
title_full_unstemmed Nature’s Timepiece—Molecular Coordination of Metabolism and Its Impact on Aging
title_short Nature’s Timepiece—Molecular Coordination of Metabolism and Its Impact on Aging
title_sort nature’s timepiece—molecular coordination of metabolism and its impact on aging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588029/
https://www.ncbi.nlm.nih.gov/pubmed/23434656
http://dx.doi.org/10.3390/ijms14023026
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