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Protein-Phospholipid Interactions in Nonclassical Protein Secretion: Problem and Methods of Study
Extracellular proteins devoid of signal peptides use nonclassical secretion mechanisms for their export. These mechanisms are independent of the endoplasmic reticulum and Golgi. Some nonclassically released proteins, particularly fibroblast growth factors (FGF) 1 and 2, are exported as a result of t...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588068/ https://www.ncbi.nlm.nih.gov/pubmed/23396106 http://dx.doi.org/10.3390/ijms14023734 |
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author | Prudovsky, Igor Kumar, Thallapuranam Krishnaswamy Suresh Sterling, Sarah Neivandt, David |
author_facet | Prudovsky, Igor Kumar, Thallapuranam Krishnaswamy Suresh Sterling, Sarah Neivandt, David |
author_sort | Prudovsky, Igor |
collection | PubMed |
description | Extracellular proteins devoid of signal peptides use nonclassical secretion mechanisms for their export. These mechanisms are independent of the endoplasmic reticulum and Golgi. Some nonclassically released proteins, particularly fibroblast growth factors (FGF) 1 and 2, are exported as a result of their direct translocation through the cell membrane. This process requires specific interactions of released proteins with membrane phospholipids. In this review written by a cell biologist, a structural biologist and two membrane engineers, we discuss the following subjects: (i) Phenomenon of nonclassical protein release and its biological significance; (ii) Composition of the FGF1 multiprotein release complex (MRC); (iii) The relationship between FGF1 export and acidic phospholipid externalization; (iv) Interactions of FGF1 MRC components with acidic phospholipids; (v) Methods to study the transmembrane translocation of proteins; (vi) Membrane models to study nonclassical protein release. |
format | Online Article Text |
id | pubmed-3588068 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-35880682013-03-13 Protein-Phospholipid Interactions in Nonclassical Protein Secretion: Problem and Methods of Study Prudovsky, Igor Kumar, Thallapuranam Krishnaswamy Suresh Sterling, Sarah Neivandt, David Int J Mol Sci Review Extracellular proteins devoid of signal peptides use nonclassical secretion mechanisms for their export. These mechanisms are independent of the endoplasmic reticulum and Golgi. Some nonclassically released proteins, particularly fibroblast growth factors (FGF) 1 and 2, are exported as a result of their direct translocation through the cell membrane. This process requires specific interactions of released proteins with membrane phospholipids. In this review written by a cell biologist, a structural biologist and two membrane engineers, we discuss the following subjects: (i) Phenomenon of nonclassical protein release and its biological significance; (ii) Composition of the FGF1 multiprotein release complex (MRC); (iii) The relationship between FGF1 export and acidic phospholipid externalization; (iv) Interactions of FGF1 MRC components with acidic phospholipids; (v) Methods to study the transmembrane translocation of proteins; (vi) Membrane models to study nonclassical protein release. MDPI 2013-02-08 /pmc/articles/PMC3588068/ /pubmed/23396106 http://dx.doi.org/10.3390/ijms14023734 Text en © 2013 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Prudovsky, Igor Kumar, Thallapuranam Krishnaswamy Suresh Sterling, Sarah Neivandt, David Protein-Phospholipid Interactions in Nonclassical Protein Secretion: Problem and Methods of Study |
title | Protein-Phospholipid Interactions in Nonclassical Protein Secretion: Problem and Methods of Study |
title_full | Protein-Phospholipid Interactions in Nonclassical Protein Secretion: Problem and Methods of Study |
title_fullStr | Protein-Phospholipid Interactions in Nonclassical Protein Secretion: Problem and Methods of Study |
title_full_unstemmed | Protein-Phospholipid Interactions in Nonclassical Protein Secretion: Problem and Methods of Study |
title_short | Protein-Phospholipid Interactions in Nonclassical Protein Secretion: Problem and Methods of Study |
title_sort | protein-phospholipid interactions in nonclassical protein secretion: problem and methods of study |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588068/ https://www.ncbi.nlm.nih.gov/pubmed/23396106 http://dx.doi.org/10.3390/ijms14023734 |
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