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The Role of F-Box Proteins during Viral Infection

The F-box domain is a protein structural motif of about 50 amino acids that mediates protein–protein interactions. The F-box protein is one of the four components of the SCF (SKp1, Cullin, F-box protein) complex, which mediates ubiquitination of proteins targeted for degradation by the proteasome, p...

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Autores principales: Correa, Régis Lopes, Bruckner, Fernanda Prieto, de Souza Cascardo, Renan, Alfenas-Zerbini, Poliane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588083/
https://www.ncbi.nlm.nih.gov/pubmed/23429191
http://dx.doi.org/10.3390/ijms14024030
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author Correa, Régis Lopes
Bruckner, Fernanda Prieto
de Souza Cascardo, Renan
Alfenas-Zerbini, Poliane
author_facet Correa, Régis Lopes
Bruckner, Fernanda Prieto
de Souza Cascardo, Renan
Alfenas-Zerbini, Poliane
author_sort Correa, Régis Lopes
collection PubMed
description The F-box domain is a protein structural motif of about 50 amino acids that mediates protein–protein interactions. The F-box protein is one of the four components of the SCF (SKp1, Cullin, F-box protein) complex, which mediates ubiquitination of proteins targeted for degradation by the proteasome, playing an essential role in many cellular processes. Several discoveries have been made on the use of the ubiquitin–proteasome system by viruses of several families to complete their infection cycle. On the other hand, F-box proteins can be used in the defense response by the host. This review describes the role of F-box proteins and the use of the ubiquitin–proteasome system in virus–host interactions.
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spelling pubmed-35880832013-03-13 The Role of F-Box Proteins during Viral Infection Correa, Régis Lopes Bruckner, Fernanda Prieto de Souza Cascardo, Renan Alfenas-Zerbini, Poliane Int J Mol Sci Review The F-box domain is a protein structural motif of about 50 amino acids that mediates protein–protein interactions. The F-box protein is one of the four components of the SCF (SKp1, Cullin, F-box protein) complex, which mediates ubiquitination of proteins targeted for degradation by the proteasome, playing an essential role in many cellular processes. Several discoveries have been made on the use of the ubiquitin–proteasome system by viruses of several families to complete their infection cycle. On the other hand, F-box proteins can be used in the defense response by the host. This review describes the role of F-box proteins and the use of the ubiquitin–proteasome system in virus–host interactions. MDPI 2013-02-18 /pmc/articles/PMC3588083/ /pubmed/23429191 http://dx.doi.org/10.3390/ijms14024030 Text en © 2013 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Correa, Régis Lopes
Bruckner, Fernanda Prieto
de Souza Cascardo, Renan
Alfenas-Zerbini, Poliane
The Role of F-Box Proteins during Viral Infection
title The Role of F-Box Proteins during Viral Infection
title_full The Role of F-Box Proteins during Viral Infection
title_fullStr The Role of F-Box Proteins during Viral Infection
title_full_unstemmed The Role of F-Box Proteins during Viral Infection
title_short The Role of F-Box Proteins during Viral Infection
title_sort role of f-box proteins during viral infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588083/
https://www.ncbi.nlm.nih.gov/pubmed/23429191
http://dx.doi.org/10.3390/ijms14024030
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