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The Role of F-Box Proteins during Viral Infection
The F-box domain is a protein structural motif of about 50 amino acids that mediates protein–protein interactions. The F-box protein is one of the four components of the SCF (SKp1, Cullin, F-box protein) complex, which mediates ubiquitination of proteins targeted for degradation by the proteasome, p...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588083/ https://www.ncbi.nlm.nih.gov/pubmed/23429191 http://dx.doi.org/10.3390/ijms14024030 |
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author | Correa, Régis Lopes Bruckner, Fernanda Prieto de Souza Cascardo, Renan Alfenas-Zerbini, Poliane |
author_facet | Correa, Régis Lopes Bruckner, Fernanda Prieto de Souza Cascardo, Renan Alfenas-Zerbini, Poliane |
author_sort | Correa, Régis Lopes |
collection | PubMed |
description | The F-box domain is a protein structural motif of about 50 amino acids that mediates protein–protein interactions. The F-box protein is one of the four components of the SCF (SKp1, Cullin, F-box protein) complex, which mediates ubiquitination of proteins targeted for degradation by the proteasome, playing an essential role in many cellular processes. Several discoveries have been made on the use of the ubiquitin–proteasome system by viruses of several families to complete their infection cycle. On the other hand, F-box proteins can be used in the defense response by the host. This review describes the role of F-box proteins and the use of the ubiquitin–proteasome system in virus–host interactions. |
format | Online Article Text |
id | pubmed-3588083 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-35880832013-03-13 The Role of F-Box Proteins during Viral Infection Correa, Régis Lopes Bruckner, Fernanda Prieto de Souza Cascardo, Renan Alfenas-Zerbini, Poliane Int J Mol Sci Review The F-box domain is a protein structural motif of about 50 amino acids that mediates protein–protein interactions. The F-box protein is one of the four components of the SCF (SKp1, Cullin, F-box protein) complex, which mediates ubiquitination of proteins targeted for degradation by the proteasome, playing an essential role in many cellular processes. Several discoveries have been made on the use of the ubiquitin–proteasome system by viruses of several families to complete their infection cycle. On the other hand, F-box proteins can be used in the defense response by the host. This review describes the role of F-box proteins and the use of the ubiquitin–proteasome system in virus–host interactions. MDPI 2013-02-18 /pmc/articles/PMC3588083/ /pubmed/23429191 http://dx.doi.org/10.3390/ijms14024030 Text en © 2013 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Correa, Régis Lopes Bruckner, Fernanda Prieto de Souza Cascardo, Renan Alfenas-Zerbini, Poliane The Role of F-Box Proteins during Viral Infection |
title | The Role of F-Box Proteins during Viral Infection |
title_full | The Role of F-Box Proteins during Viral Infection |
title_fullStr | The Role of F-Box Proteins during Viral Infection |
title_full_unstemmed | The Role of F-Box Proteins during Viral Infection |
title_short | The Role of F-Box Proteins during Viral Infection |
title_sort | role of f-box proteins during viral infection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588083/ https://www.ncbi.nlm.nih.gov/pubmed/23429191 http://dx.doi.org/10.3390/ijms14024030 |
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