Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis

Chemical examination of the Taiwanese soft coral Sinularia flexibilis led to the isolation of five cembrane-based diterpenoids 1–5, including two new metabolites, 11-acetylsinuflexolide (1) and 11-acetyldihydrosinuflexolide (2). The structures of the new metabolites were determined based on extensiv...

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Detalles Bibliográficos
Autores principales: Su, Ching-Chyuan, Wong, Bing-Sang, Chin, Chuen, Wu, Yu-Jen, Su, Jui-Hsin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588100/
https://www.ncbi.nlm.nih.gov/pubmed/23429272
http://dx.doi.org/10.3390/ijms14024317
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author Su, Ching-Chyuan
Wong, Bing-Sang
Chin, Chuen
Wu, Yu-Jen
Su, Jui-Hsin
author_facet Su, Ching-Chyuan
Wong, Bing-Sang
Chin, Chuen
Wu, Yu-Jen
Su, Jui-Hsin
author_sort Su, Ching-Chyuan
collection PubMed
description Chemical examination of the Taiwanese soft coral Sinularia flexibilis led to the isolation of five cembrane-based diterpenoids 1–5, including two new metabolites, 11-acetylsinuflexolide (1) and 11-acetyldihydrosinuflexolide (2). The structures of the new metabolites were determined based on extensive spectroscopic analysis, particularly mass spectrometry and 2D NMR ((1)H–(1)H COSY, HMQC, HMBC, and NOESY) spectroscopy. Metabolites 1, 3 and 4 exhibited moderate to weak cytotoxicity to human tumor cell lines, HeLa, HEp-2, MCF-7 and MDA-MB-231.
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spelling pubmed-35881002013-03-13 Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis Su, Ching-Chyuan Wong, Bing-Sang Chin, Chuen Wu, Yu-Jen Su, Jui-Hsin Int J Mol Sci Article Chemical examination of the Taiwanese soft coral Sinularia flexibilis led to the isolation of five cembrane-based diterpenoids 1–5, including two new metabolites, 11-acetylsinuflexolide (1) and 11-acetyldihydrosinuflexolide (2). The structures of the new metabolites were determined based on extensive spectroscopic analysis, particularly mass spectrometry and 2D NMR ((1)H–(1)H COSY, HMQC, HMBC, and NOESY) spectroscopy. Metabolites 1, 3 and 4 exhibited moderate to weak cytotoxicity to human tumor cell lines, HeLa, HEp-2, MCF-7 and MDA-MB-231. MDPI 2013-02-21 /pmc/articles/PMC3588100/ /pubmed/23429272 http://dx.doi.org/10.3390/ijms14024317 Text en © 2013 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Su, Ching-Chyuan
Wong, Bing-Sang
Chin, Chuen
Wu, Yu-Jen
Su, Jui-Hsin
Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis
title Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis
title_full Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis
title_fullStr Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis
title_full_unstemmed Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis
title_short Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis
title_sort oxygenated cembranoids from the soft coral sinularia flexibilis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588100/
https://www.ncbi.nlm.nih.gov/pubmed/23429272
http://dx.doi.org/10.3390/ijms14024317
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AT wuyujen oxygenatedcembranoidsfromthesoftcoralsinulariaflexibilis
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