Stable polymorph of morphine

In the stable polymorph of the title compound, C(17)H(19)NO(3) [systematic name: (5α,6α)-7,8-didehydro-4,5-ep­oxy-17-methyl­morphinan-3,6-diol], the mol­ecular conformation is in agreement with the characteristics of previously reported morphine forms. The molecule displays the typical T-shape and i...

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Detalles Bibliográficos
Autores principales: Gelbrich, Thomas, Braun, Doris E., Griesser, Ulrich J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2012
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588323/
https://www.ncbi.nlm.nih.gov/pubmed/23476407
http://dx.doi.org/10.1107/S1600536812048945
Descripción
Sumario:In the stable polymorph of the title compound, C(17)H(19)NO(3) [systematic name: (5α,6α)-7,8-didehydro-4,5-ep­oxy-17-methyl­morphinan-3,6-diol], the mol­ecular conformation is in agreement with the characteristics of previously reported morphine forms. The molecule displays the typical T-shape and its piperidine ring adopts a slightly distorted chair conformation. Inter­molecular O—H⋯O hydrogen bonds link the mol­ecules into helical chains parallel to the b axis. Intra­molecular O—H⋯O hydrogen bonds are also observed.

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