Stable polymorph of morphine

In the stable polymorph of the title compound, C(17)H(19)NO(3) [systematic name: (5α,6α)-7,8-didehydro-4,5-ep­oxy-17-methyl­morphinan-3,6-diol], the mol­ecular conformation is in agreement with the characteristics of previously reported morphine forms. The molecule displays the typical T-shape and i...

Descripción completa

Detalles Bibliográficos
Autores principales: Gelbrich, Thomas, Braun, Doris E., Griesser, Ulrich J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2012
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588323/
https://www.ncbi.nlm.nih.gov/pubmed/23476407
http://dx.doi.org/10.1107/S1600536812048945
_version_ 1782261539400581120
author Gelbrich, Thomas
Braun, Doris E.
Griesser, Ulrich J.
author_facet Gelbrich, Thomas
Braun, Doris E.
Griesser, Ulrich J.
author_sort Gelbrich, Thomas
collection PubMed
description In the stable polymorph of the title compound, C(17)H(19)NO(3) [systematic name: (5α,6α)-7,8-didehydro-4,5-ep­oxy-17-methyl­morphinan-3,6-diol], the mol­ecular conformation is in agreement with the characteristics of previously reported morphine forms. The molecule displays the typical T-shape and its piperidine ring adopts a slightly distorted chair conformation. Inter­molecular O—H⋯O hydrogen bonds link the mol­ecules into helical chains parallel to the b axis. Intra­molecular O—H⋯O hydrogen bonds are also observed.
format Online
Article
Text
id pubmed-3588323
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher International Union of Crystallography
record_format MEDLINE/PubMed
spelling pubmed-35883232013-03-08 Stable polymorph of morphine Gelbrich, Thomas Braun, Doris E. Griesser, Ulrich J. Acta Crystallogr Sect E Struct Rep Online Organic Papers In the stable polymorph of the title compound, C(17)H(19)NO(3) [systematic name: (5α,6α)-7,8-didehydro-4,5-ep­oxy-17-methyl­morphinan-3,6-diol], the mol­ecular conformation is in agreement with the characteristics of previously reported morphine forms. The molecule displays the typical T-shape and its piperidine ring adopts a slightly distorted chair conformation. Inter­molecular O—H⋯O hydrogen bonds link the mol­ecules into helical chains parallel to the b axis. Intra­molecular O—H⋯O hydrogen bonds are also observed. International Union of Crystallography 2012-12-05 /pmc/articles/PMC3588323/ /pubmed/23476407 http://dx.doi.org/10.1107/S1600536812048945 Text en © Gelbrich et al. 2013 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Gelbrich, Thomas
Braun, Doris E.
Griesser, Ulrich J.
Stable polymorph of morphine
title Stable polymorph of morphine
title_full Stable polymorph of morphine
title_fullStr Stable polymorph of morphine
title_full_unstemmed Stable polymorph of morphine
title_short Stable polymorph of morphine
title_sort stable polymorph of morphine
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588323/
https://www.ncbi.nlm.nih.gov/pubmed/23476407
http://dx.doi.org/10.1107/S1600536812048945
work_keys_str_mv AT gelbrichthomas stablepolymorphofmorphine
AT braundorise stablepolymorphofmorphine
AT griesserulrichj stablepolymorphofmorphine

Ejemplares similares