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rac-5′′-(4-Fluorobenzylidene)-1′-(4-fluorophenyl)-1′′-methyl-1′,2′,3′,5′,6′,7′,8′,8a′-octahydrodispiro[acenaphthylene-1,3′-indolizine-2′,3′′-piperidine]-2,4′′(1H)-dione
In the title E isomer of the racemic compound, C(37)H(32)F(2)N(2)O(2), the pyridinone ring adopts a twisted half-chair conformation with the N atom deviating by −0.355 (3) Å and with the methylene C atom next to octahydroindolizine moiety deviating by 0.415 (3) Å from the mean plane defined by ot...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588349/ https://www.ncbi.nlm.nih.gov/pubmed/23476397 http://dx.doi.org/10.1107/S1600536812051094 |
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author | Suresh, J. Nagalakshmi, R. A. Sivakumar, S. Kumar, R. Ranjith Lakshman, P. L. Nilantha |
author_facet | Suresh, J. Nagalakshmi, R. A. Sivakumar, S. Kumar, R. Ranjith Lakshman, P. L. Nilantha |
author_sort | Suresh, J. |
collection | PubMed |
description | In the title E isomer of the racemic compound, C(37)H(32)F(2)N(2)O(2), the pyridinone ring adopts a twisted half-chair conformation with the N atom deviating by −0.355 (3) Å and with the methylene C atom next to octahydroindolizine moiety deviating by 0.415 (3) Å from the mean plane defined by other four atoms. In the octahydroindolizine system, the pyrrolidine ring exhibits an envelope conformation with the fused methyne C atom deviating by 0.6496 (1) Å from the mean plane defined by four other atoms, and the piperidine ring exhibits a distorted chair conformation as evident from the puckering parameters Q = 0.568 (2) Å, θ = 1.0 (2) and Φ = 256 (11)°. In the crystal, C—H⋯O interactions connect the molecules into chains along [101]. |
format | Online Article Text |
id | pubmed-3588349 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-35883492013-03-08 rac-5′′-(4-Fluorobenzylidene)-1′-(4-fluorophenyl)-1′′-methyl-1′,2′,3′,5′,6′,7′,8′,8a′-octahydrodispiro[acenaphthylene-1,3′-indolizine-2′,3′′-piperidine]-2,4′′(1H)-dione Suresh, J. Nagalakshmi, R. A. Sivakumar, S. Kumar, R. Ranjith Lakshman, P. L. Nilantha Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title E isomer of the racemic compound, C(37)H(32)F(2)N(2)O(2), the pyridinone ring adopts a twisted half-chair conformation with the N atom deviating by −0.355 (3) Å and with the methylene C atom next to octahydroindolizine moiety deviating by 0.415 (3) Å from the mean plane defined by other four atoms. In the octahydroindolizine system, the pyrrolidine ring exhibits an envelope conformation with the fused methyne C atom deviating by 0.6496 (1) Å from the mean plane defined by four other atoms, and the piperidine ring exhibits a distorted chair conformation as evident from the puckering parameters Q = 0.568 (2) Å, θ = 1.0 (2) and Φ = 256 (11)°. In the crystal, C—H⋯O interactions connect the molecules into chains along [101]. International Union of Crystallography 2012-12-22 /pmc/articles/PMC3588349/ /pubmed/23476397 http://dx.doi.org/10.1107/S1600536812051094 Text en © Suresh et al. 2013 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Organic Papers Suresh, J. Nagalakshmi, R. A. Sivakumar, S. Kumar, R. Ranjith Lakshman, P. L. Nilantha rac-5′′-(4-Fluorobenzylidene)-1′-(4-fluorophenyl)-1′′-methyl-1′,2′,3′,5′,6′,7′,8′,8a′-octahydrodispiro[acenaphthylene-1,3′-indolizine-2′,3′′-piperidine]-2,4′′(1H)-dione |
title |
rac-5′′-(4-Fluorobenzylidene)-1′-(4-fluorophenyl)-1′′-methyl-1′,2′,3′,5′,6′,7′,8′,8a′-octahydrodispiro[acenaphthylene-1,3′-indolizine-2′,3′′-piperidine]-2,4′′(1H)-dione |
title_full |
rac-5′′-(4-Fluorobenzylidene)-1′-(4-fluorophenyl)-1′′-methyl-1′,2′,3′,5′,6′,7′,8′,8a′-octahydrodispiro[acenaphthylene-1,3′-indolizine-2′,3′′-piperidine]-2,4′′(1H)-dione |
title_fullStr |
rac-5′′-(4-Fluorobenzylidene)-1′-(4-fluorophenyl)-1′′-methyl-1′,2′,3′,5′,6′,7′,8′,8a′-octahydrodispiro[acenaphthylene-1,3′-indolizine-2′,3′′-piperidine]-2,4′′(1H)-dione |
title_full_unstemmed |
rac-5′′-(4-Fluorobenzylidene)-1′-(4-fluorophenyl)-1′′-methyl-1′,2′,3′,5′,6′,7′,8′,8a′-octahydrodispiro[acenaphthylene-1,3′-indolizine-2′,3′′-piperidine]-2,4′′(1H)-dione |
title_short |
rac-5′′-(4-Fluorobenzylidene)-1′-(4-fluorophenyl)-1′′-methyl-1′,2′,3′,5′,6′,7′,8′,8a′-octahydrodispiro[acenaphthylene-1,3′-indolizine-2′,3′′-piperidine]-2,4′′(1H)-dione |
title_sort | rac-5′′-(4-fluorobenzylidene)-1′-(4-fluorophenyl)-1′′-methyl-1′,2′,3′,5′,6′,7′,8′,8a′-octahydrodispiro[acenaphthylene-1,3′-indolizine-2′,3′′-piperidine]-2,4′′(1h)-dione |
topic | Organic Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588349/ https://www.ncbi.nlm.nih.gov/pubmed/23476397 http://dx.doi.org/10.1107/S1600536812051094 |
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