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2-[N-(4-Methoxyphenyl)acetamido]-1,3-thiazol-4-yl acetate
The structural analysis of the title compound, C(14)H(14)N(2)O(4)S, particularly the presence of an acetyl group at the exocyclic N atom and the C(H)—C(O(2)CMe)—N acetoxy group in the thiazole ring, may indicate that one of the starting materials, i.e. 2-(4-methoxyanilino)-1,3-thiazol-4(5H)-one...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588441/ https://www.ncbi.nlm.nih.gov/pubmed/23476576 http://dx.doi.org/10.1107/S1600536813004236 |
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author | Horishny, Volodymyr Lesyk, Roman Gzella, Andrzej K. |
author_facet | Horishny, Volodymyr Lesyk, Roman Gzella, Andrzej K. |
author_sort | Horishny, Volodymyr |
collection | PubMed |
description | The structural analysis of the title compound, C(14)H(14)N(2)O(4)S, particularly the presence of an acetyl group at the exocyclic N atom and the C(H)—C(O(2)CMe)—N acetoxy group in the thiazole ring, may indicate that one of the starting materials, i.e. 2-(4-methoxyanilino)-1,3-thiazol-4(5H)-one, exists in the reaction mixture, at least partially, as a tautomer with an exocyclic amine N atom and an enol group. The acetoxy and acetyl groups deviate from the thiazole plane by 69.17 (6) and 7.25 (19)°, respectively. The thiazole and benzene rings form a dihedral angle of 73.50 (4)°. In the crystal, centrosymmetrically related molecules are connected into dimeric aggregates via C—H⋯O interactions. |
format | Online Article Text |
id | pubmed-3588441 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-35884412013-03-08 2-[N-(4-Methoxyphenyl)acetamido]-1,3-thiazol-4-yl acetate Horishny, Volodymyr Lesyk, Roman Gzella, Andrzej K. Acta Crystallogr Sect E Struct Rep Online Organic Papers The structural analysis of the title compound, C(14)H(14)N(2)O(4)S, particularly the presence of an acetyl group at the exocyclic N atom and the C(H)—C(O(2)CMe)—N acetoxy group in the thiazole ring, may indicate that one of the starting materials, i.e. 2-(4-methoxyanilino)-1,3-thiazol-4(5H)-one, exists in the reaction mixture, at least partially, as a tautomer with an exocyclic amine N atom and an enol group. The acetoxy and acetyl groups deviate from the thiazole plane by 69.17 (6) and 7.25 (19)°, respectively. The thiazole and benzene rings form a dihedral angle of 73.50 (4)°. In the crystal, centrosymmetrically related molecules are connected into dimeric aggregates via C—H⋯O interactions. International Union of Crystallography 2013-02-16 /pmc/articles/PMC3588441/ /pubmed/23476576 http://dx.doi.org/10.1107/S1600536813004236 Text en © Horishny et al. 2013 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Organic Papers Horishny, Volodymyr Lesyk, Roman Gzella, Andrzej K. 2-[N-(4-Methoxyphenyl)acetamido]-1,3-thiazol-4-yl acetate |
title | 2-[N-(4-Methoxyphenyl)acetamido]-1,3-thiazol-4-yl acetate |
title_full | 2-[N-(4-Methoxyphenyl)acetamido]-1,3-thiazol-4-yl acetate |
title_fullStr | 2-[N-(4-Methoxyphenyl)acetamido]-1,3-thiazol-4-yl acetate |
title_full_unstemmed | 2-[N-(4-Methoxyphenyl)acetamido]-1,3-thiazol-4-yl acetate |
title_short | 2-[N-(4-Methoxyphenyl)acetamido]-1,3-thiazol-4-yl acetate |
title_sort | 2-[n-(4-methoxyphenyl)acetamido]-1,3-thiazol-4-yl acetate |
topic | Organic Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588441/ https://www.ncbi.nlm.nih.gov/pubmed/23476576 http://dx.doi.org/10.1107/S1600536813004236 |
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