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2-[N-(2,4-Dimeth­oxy­phen­yl)acetamido]-1,3-thia­zol-4-yl acetate

The title compound, C(15)H(16)N(2)O(5)S, is a product of the reaction of 2-(2,4-dimeth­oxy­phenyl­amino)-1,3-thia­zol-4(5H)-one with acetic anhydride. The presence of the acetyl and acet­oxy groups in the mol­ecule indicates that the starting thia­zole exists as a tautomer in the reaction mixture wi...

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Autores principales: Horishny, Volodymyr, Lesyk, Roman, Kowiel, Marcin, Gzella, Andrzej K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588517/
https://www.ncbi.nlm.nih.gov/pubmed/23476547
http://dx.doi.org/10.1107/S1600536813003474
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author Horishny, Volodymyr
Lesyk, Roman
Kowiel, Marcin
Gzella, Andrzej K.
author_facet Horishny, Volodymyr
Lesyk, Roman
Kowiel, Marcin
Gzella, Andrzej K.
author_sort Horishny, Volodymyr
collection PubMed
description The title compound, C(15)H(16)N(2)O(5)S, is a product of the reaction of 2-(2,4-dimeth­oxy­phenyl­amino)-1,3-thia­zol-4(5H)-one with acetic anhydride. The presence of the acetyl and acet­oxy groups in the mol­ecule indicates that the starting thia­zole exists as a tautomer in the reaction mixture with exocyclic amino and enol moieties. The acetyl group is tilted slightly from the heterocyclic ring plane [dihedral angle = 4.46 (11)°], while the acet­oxy group is almost perpendicular to this ring [dihedral angle = 88.14 (12)°]. An intra­molecular acet­yl–meth­oxy C—H⋯O inter­action is noted. In the crystal, mol­ecules are connected into a three-dimensional architecture by C—H⋯O inter­actions.
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spelling pubmed-35885172013-03-08 2-[N-(2,4-Dimeth­oxy­phen­yl)acetamido]-1,3-thia­zol-4-yl acetate Horishny, Volodymyr Lesyk, Roman Kowiel, Marcin Gzella, Andrzej K. Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(15)H(16)N(2)O(5)S, is a product of the reaction of 2-(2,4-dimeth­oxy­phenyl­amino)-1,3-thia­zol-4(5H)-one with acetic anhydride. The presence of the acetyl and acet­oxy groups in the mol­ecule indicates that the starting thia­zole exists as a tautomer in the reaction mixture with exocyclic amino and enol moieties. The acetyl group is tilted slightly from the heterocyclic ring plane [dihedral angle = 4.46 (11)°], while the acet­oxy group is almost perpendicular to this ring [dihedral angle = 88.14 (12)°]. An intra­molecular acet­yl–meth­oxy C—H⋯O inter­action is noted. In the crystal, mol­ecules are connected into a three-dimensional architecture by C—H⋯O inter­actions. International Union of Crystallography 2013-02-09 /pmc/articles/PMC3588517/ /pubmed/23476547 http://dx.doi.org/10.1107/S1600536813003474 Text en © Horishny et al. 2013 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Horishny, Volodymyr
Lesyk, Roman
Kowiel, Marcin
Gzella, Andrzej K.
2-[N-(2,4-Dimeth­oxy­phen­yl)acetamido]-1,3-thia­zol-4-yl acetate
title 2-[N-(2,4-Dimeth­oxy­phen­yl)acetamido]-1,3-thia­zol-4-yl acetate
title_full 2-[N-(2,4-Dimeth­oxy­phen­yl)acetamido]-1,3-thia­zol-4-yl acetate
title_fullStr 2-[N-(2,4-Dimeth­oxy­phen­yl)acetamido]-1,3-thia­zol-4-yl acetate
title_full_unstemmed 2-[N-(2,4-Dimeth­oxy­phen­yl)acetamido]-1,3-thia­zol-4-yl acetate
title_short 2-[N-(2,4-Dimeth­oxy­phen­yl)acetamido]-1,3-thia­zol-4-yl acetate
title_sort 2-[n-(2,4-dimeth­oxy­phen­yl)acetamido]-1,3-thia­zol-4-yl acetate
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588517/
https://www.ncbi.nlm.nih.gov/pubmed/23476547
http://dx.doi.org/10.1107/S1600536813003474
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