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(1′S,4′S)-5-(2,5-Dimethyl­phen­yl)-4′-meth­oxy-6-oxa-3-aza­spiro­[bicyclo­[3.1.0]hexane-2,1′-cyclo­hexa­n]-4-one

In the title compound, C(18)H(23)NO(3), the cyclo­hexane ring has a chair conformation. The oxirane plane (OCC) makes a dihedral angle of 76.15 (13)° with that of the pyrrolidine ring to which it is fused. The mean plane of the cyclo­hexane ring and the benzene ring are almost normal to the pyrrolid...

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Autores principales: He, Xing-Rui, Xu, Bing-Rong, Cheng, Jing-Li, Zhao, Jin-Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588543/
https://www.ncbi.nlm.nih.gov/pubmed/23476621
http://dx.doi.org/10.1107/S1600536813005138
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author He, Xing-Rui
Xu, Bing-Rong
Cheng, Jing-Li
Zhao, Jin-Hao
author_facet He, Xing-Rui
Xu, Bing-Rong
Cheng, Jing-Li
Zhao, Jin-Hao
author_sort He, Xing-Rui
collection PubMed
description In the title compound, C(18)H(23)NO(3), the cyclo­hexane ring has a chair conformation. The oxirane plane (OCC) makes a dihedral angle of 76.15 (13)° with that of the pyrrolidine ring to which it is fused. The mean plane of the cyclo­hexane ring and the benzene ring are almost normal to the pyrrolidine ring, with dihedral angles of 88.47 (8) and 77.85 (8)°, respectively. In the crystal, mol­ecules are linked via pairs of N—H⋯O hydrogen bonds, forming inversion dimers. These dimers are linked via pairs of C—H⋯O hydrogen bonds, forming chains along the a-axis direction.
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spelling pubmed-35885432013-03-08 (1′S,4′S)-5-(2,5-Dimethyl­phen­yl)-4′-meth­oxy-6-oxa-3-aza­spiro­[bicyclo­[3.1.0]hexane-2,1′-cyclo­hexa­n]-4-one He, Xing-Rui Xu, Bing-Rong Cheng, Jing-Li Zhao, Jin-Hao Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title compound, C(18)H(23)NO(3), the cyclo­hexane ring has a chair conformation. The oxirane plane (OCC) makes a dihedral angle of 76.15 (13)° with that of the pyrrolidine ring to which it is fused. The mean plane of the cyclo­hexane ring and the benzene ring are almost normal to the pyrrolidine ring, with dihedral angles of 88.47 (8) and 77.85 (8)°, respectively. In the crystal, mol­ecules are linked via pairs of N—H⋯O hydrogen bonds, forming inversion dimers. These dimers are linked via pairs of C—H⋯O hydrogen bonds, forming chains along the a-axis direction. International Union of Crystallography 2013-02-28 /pmc/articles/PMC3588543/ /pubmed/23476621 http://dx.doi.org/10.1107/S1600536813005138 Text en © He et al. 2013 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
He, Xing-Rui
Xu, Bing-Rong
Cheng, Jing-Li
Zhao, Jin-Hao
(1′S,4′S)-5-(2,5-Dimethyl­phen­yl)-4′-meth­oxy-6-oxa-3-aza­spiro­[bicyclo­[3.1.0]hexane-2,1′-cyclo­hexa­n]-4-one
title (1′S,4′S)-5-(2,5-Dimethyl­phen­yl)-4′-meth­oxy-6-oxa-3-aza­spiro­[bicyclo­[3.1.0]hexane-2,1′-cyclo­hexa­n]-4-one
title_full (1′S,4′S)-5-(2,5-Dimethyl­phen­yl)-4′-meth­oxy-6-oxa-3-aza­spiro­[bicyclo­[3.1.0]hexane-2,1′-cyclo­hexa­n]-4-one
title_fullStr (1′S,4′S)-5-(2,5-Dimethyl­phen­yl)-4′-meth­oxy-6-oxa-3-aza­spiro­[bicyclo­[3.1.0]hexane-2,1′-cyclo­hexa­n]-4-one
title_full_unstemmed (1′S,4′S)-5-(2,5-Dimethyl­phen­yl)-4′-meth­oxy-6-oxa-3-aza­spiro­[bicyclo­[3.1.0]hexane-2,1′-cyclo­hexa­n]-4-one
title_short (1′S,4′S)-5-(2,5-Dimethyl­phen­yl)-4′-meth­oxy-6-oxa-3-aza­spiro­[bicyclo­[3.1.0]hexane-2,1′-cyclo­hexa­n]-4-one
title_sort (1′s,4′s)-5-(2,5-dimethyl­phen­yl)-4′-meth­oxy-6-oxa-3-aza­spiro­[bicyclo­[3.1.0]hexane-2,1′-cyclo­hexa­n]-4-one
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588543/
https://www.ncbi.nlm.nih.gov/pubmed/23476621
http://dx.doi.org/10.1107/S1600536813005138
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