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Progressive disseminated histoplasmosis presenting with cachexia and hypercalcemia

Histoplasmosis is a common endemic mycosis. The majority of infections involving this dimorphic fungus are asymptomatic. Manifestations in symptomatic patients are diverse, ranging from flu-like illness to a more serious disseminated disease. We present here a case of chronic disseminated histoplasm...

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Autores principales: Khasawneh, Faisal A, Ahmed, Subhan, Halloush, Ruba A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588607/
https://www.ncbi.nlm.nih.gov/pubmed/23467543
http://dx.doi.org/10.2147/IJGM.S41520
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author Khasawneh, Faisal A
Ahmed, Subhan
Halloush, Ruba A
author_facet Khasawneh, Faisal A
Ahmed, Subhan
Halloush, Ruba A
author_sort Khasawneh, Faisal A
collection PubMed
description Histoplasmosis is a common endemic mycosis. The majority of infections involving this dimorphic fungus are asymptomatic. Manifestations in symptomatic patients are diverse, ranging from flu-like illness to a more serious disseminated disease. We present here a case of chronic disseminated histoplasmosis mimicking a metastatic cancer. We reviewed the literature for cases of disseminated histoplasmosis presenting with hypercalcemia, focusing particularly on clinical presentation, risk factors predisposing for fungal infection, and outcome. We report a case of a 65-year-old diabetic male who presented with unexplained weight loss and hypercalcemia. Multiple brain space-occupying lesions and bilateral adrenal enlargement were evident on imaging studies. Biopsies showed caseating granulomas with budding yeast, consistent with histoplasmosis. The patient’s symptoms resolved after liposomal amphotericin B and itraconazole therapy. Granulomatous diseases, including fungal infections, should be considered alongside malignancies, in patients with similar presentation.
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spelling pubmed-35886072013-03-06 Progressive disseminated histoplasmosis presenting with cachexia and hypercalcemia Khasawneh, Faisal A Ahmed, Subhan Halloush, Ruba A Int J Gen Med Case Report Histoplasmosis is a common endemic mycosis. The majority of infections involving this dimorphic fungus are asymptomatic. Manifestations in symptomatic patients are diverse, ranging from flu-like illness to a more serious disseminated disease. We present here a case of chronic disseminated histoplasmosis mimicking a metastatic cancer. We reviewed the literature for cases of disseminated histoplasmosis presenting with hypercalcemia, focusing particularly on clinical presentation, risk factors predisposing for fungal infection, and outcome. We report a case of a 65-year-old diabetic male who presented with unexplained weight loss and hypercalcemia. Multiple brain space-occupying lesions and bilateral adrenal enlargement were evident on imaging studies. Biopsies showed caseating granulomas with budding yeast, consistent with histoplasmosis. The patient’s symptoms resolved after liposomal amphotericin B and itraconazole therapy. Granulomatous diseases, including fungal infections, should be considered alongside malignancies, in patients with similar presentation. Dove Medical Press 2013-02-27 /pmc/articles/PMC3588607/ /pubmed/23467543 http://dx.doi.org/10.2147/IJGM.S41520 Text en © 2013 Khasawneh et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Case Report
Khasawneh, Faisal A
Ahmed, Subhan
Halloush, Ruba A
Progressive disseminated histoplasmosis presenting with cachexia and hypercalcemia
title Progressive disseminated histoplasmosis presenting with cachexia and hypercalcemia
title_full Progressive disseminated histoplasmosis presenting with cachexia and hypercalcemia
title_fullStr Progressive disseminated histoplasmosis presenting with cachexia and hypercalcemia
title_full_unstemmed Progressive disseminated histoplasmosis presenting with cachexia and hypercalcemia
title_short Progressive disseminated histoplasmosis presenting with cachexia and hypercalcemia
title_sort progressive disseminated histoplasmosis presenting with cachexia and hypercalcemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588607/
https://www.ncbi.nlm.nih.gov/pubmed/23467543
http://dx.doi.org/10.2147/IJGM.S41520
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