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Progressive disseminated histoplasmosis presenting with cachexia and hypercalcemia
Histoplasmosis is a common endemic mycosis. The majority of infections involving this dimorphic fungus are asymptomatic. Manifestations in symptomatic patients are diverse, ranging from flu-like illness to a more serious disseminated disease. We present here a case of chronic disseminated histoplasm...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588607/ https://www.ncbi.nlm.nih.gov/pubmed/23467543 http://dx.doi.org/10.2147/IJGM.S41520 |
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author | Khasawneh, Faisal A Ahmed, Subhan Halloush, Ruba A |
author_facet | Khasawneh, Faisal A Ahmed, Subhan Halloush, Ruba A |
author_sort | Khasawneh, Faisal A |
collection | PubMed |
description | Histoplasmosis is a common endemic mycosis. The majority of infections involving this dimorphic fungus are asymptomatic. Manifestations in symptomatic patients are diverse, ranging from flu-like illness to a more serious disseminated disease. We present here a case of chronic disseminated histoplasmosis mimicking a metastatic cancer. We reviewed the literature for cases of disseminated histoplasmosis presenting with hypercalcemia, focusing particularly on clinical presentation, risk factors predisposing for fungal infection, and outcome. We report a case of a 65-year-old diabetic male who presented with unexplained weight loss and hypercalcemia. Multiple brain space-occupying lesions and bilateral adrenal enlargement were evident on imaging studies. Biopsies showed caseating granulomas with budding yeast, consistent with histoplasmosis. The patient’s symptoms resolved after liposomal amphotericin B and itraconazole therapy. Granulomatous diseases, including fungal infections, should be considered alongside malignancies, in patients with similar presentation. |
format | Online Article Text |
id | pubmed-3588607 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-35886072013-03-06 Progressive disseminated histoplasmosis presenting with cachexia and hypercalcemia Khasawneh, Faisal A Ahmed, Subhan Halloush, Ruba A Int J Gen Med Case Report Histoplasmosis is a common endemic mycosis. The majority of infections involving this dimorphic fungus are asymptomatic. Manifestations in symptomatic patients are diverse, ranging from flu-like illness to a more serious disseminated disease. We present here a case of chronic disseminated histoplasmosis mimicking a metastatic cancer. We reviewed the literature for cases of disseminated histoplasmosis presenting with hypercalcemia, focusing particularly on clinical presentation, risk factors predisposing for fungal infection, and outcome. We report a case of a 65-year-old diabetic male who presented with unexplained weight loss and hypercalcemia. Multiple brain space-occupying lesions and bilateral adrenal enlargement were evident on imaging studies. Biopsies showed caseating granulomas with budding yeast, consistent with histoplasmosis. The patient’s symptoms resolved after liposomal amphotericin B and itraconazole therapy. Granulomatous diseases, including fungal infections, should be considered alongside malignancies, in patients with similar presentation. Dove Medical Press 2013-02-27 /pmc/articles/PMC3588607/ /pubmed/23467543 http://dx.doi.org/10.2147/IJGM.S41520 Text en © 2013 Khasawneh et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Case Report Khasawneh, Faisal A Ahmed, Subhan Halloush, Ruba A Progressive disseminated histoplasmosis presenting with cachexia and hypercalcemia |
title | Progressive disseminated histoplasmosis presenting with cachexia and hypercalcemia |
title_full | Progressive disseminated histoplasmosis presenting with cachexia and hypercalcemia |
title_fullStr | Progressive disseminated histoplasmosis presenting with cachexia and hypercalcemia |
title_full_unstemmed | Progressive disseminated histoplasmosis presenting with cachexia and hypercalcemia |
title_short | Progressive disseminated histoplasmosis presenting with cachexia and hypercalcemia |
title_sort | progressive disseminated histoplasmosis presenting with cachexia and hypercalcemia |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588607/ https://www.ncbi.nlm.nih.gov/pubmed/23467543 http://dx.doi.org/10.2147/IJGM.S41520 |
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