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3-[(Furan-2-yl)carbon­yl]-1-(pyrimi­din-2-yl)thio­urea

The title compound, C(10)H(8)N(4)O(2)S, was synthesized from furoyl isothio­cynate and 2-amino­pyrimidine in dry acetone. The two N—H groups are in an anti conformation with respect to each other and one N—H group is anti to the C=S group while the other is syn. The amide C=S and the C=O groups are...

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Detalles Bibliográficos
Autores principales: Singh, Durga P., Pratap, Seema, Gupta, Sushil K., Butcher, Ray J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588843/
https://www.ncbi.nlm.nih.gov/pubmed/23468808
http://dx.doi.org/10.1107/S1600536812044029
Descripción
Sumario:The title compound, C(10)H(8)N(4)O(2)S, was synthesized from furoyl isothio­cynate and 2-amino­pyrimidine in dry acetone. The two N—H groups are in an anti conformation with respect to each other and one N—H group is anti to the C=S group while the other is syn. The amide C=S and the C=O groups are syn to each other. The mean plane of the central thio­urea fragment forms dihedral angles of 13.50 (14) and 5.03 (11)° with the furan and pyrimidine rings, respectively. The dihedral angle between the furan and pyrimidine rings is 18.43 (10)°. The mol­ecular conformation is stabilized by an intra­molecular N—H⋯N hydrogen bond generating an S(6) ring motif. In the crystal, mol­ecules are linked by pairs of N—H⋯N and weak C—H⋯S hydrogen bonds to form inversion dimers.