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Epigenetic epistatic interactions constrain the evolution of gene expression
Reduced activity of two genes in combination often has a more detrimental effect than expected. Such epistatic interactions not only occur when genes are mutated but also due to variation in gene expression, including among isogenic individuals in a controlled environment. We hypothesized that these...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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European Molecular Biology Organization
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588906/ https://www.ncbi.nlm.nih.gov/pubmed/23423319 http://dx.doi.org/10.1038/msb.2013.2 |