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N-[4-(9-Chloroquino[3,2-b]benzo[1,4]thiazin-6-yl)butyl]acetamide
In the title molecule, C(21)H(20)ClN(3)OS, the tetracyclic system is close to planar [r.m.s. deviation = 0.110 (4) Å]. The dihedral angle between the quinoline ring system and the benzene ring is 178.3 (1)° and the angle between two (S—C=C—N) halves of the thiazine ring is 173.4 (1)°. In the crys...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588930/ https://www.ncbi.nlm.nih.gov/pubmed/23476166 http://dx.doi.org/10.1107/S1600536812045680 |
Sumario: | In the title molecule, C(21)H(20)ClN(3)OS, the tetracyclic system is close to planar [r.m.s. deviation = 0.110 (4) Å]. The dihedral angle between the quinoline ring system and the benzene ring is 178.3 (1)° and the angle between two (S—C=C—N) halves of the thiazine ring is 173.4 (1)°. In the crystal, molecules are arranged via π–π interactions [centroid–centroid distances = 3.603 (2)–3.739 (2) Å] into slipped stacks extending along [010]. Intermolecular N—H⋯O hydrogen bonds link the amide groups of neighbouring molecules along the stack, generating a C(4) motif. The title compound shows promising antiproliferative and anticancer activity. |
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