Methyl 12-hydroxy-10-[1-(4-meth­oxy­phen­yl)-2-oxo-3-phen­oxy­azetidin-4-yl]-11-oxa-3-aza­hexa­cyclo­[11.7.1.0(2,9).0(2,12).0(3,7).0(17,21)]henicosa-1(20),13,15,17(21),18-penta­ene-9-carboxyl­ate

In the title compound, C(37)H(34)N(2)O(7), both pyrrolidine rings adopt envelope conformations. The β-lactam ring is close to planar (r.m.s. deviation = 0.0395 Å) and makes a dihedral angle of 83.35 (15)° with the furan ring. The O atom attached to the β-lactam ring deviates by 0.187 (2) Å from the...

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Autores principales: Suhitha, Sivasubramanian, Srinivasan, Thothadri, Rajesh, Raju, Raghunathan, Raghavachary, Velmurugan, Devadasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2012
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588933/
https://www.ncbi.nlm.nih.gov/pubmed/23476169
http://dx.doi.org/10.1107/S1600536812045795
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author Suhitha, Sivasubramanian
Srinivasan, Thothadri
Rajesh, Raju
Raghunathan, Raghavachary
Velmurugan, Devadasan
author_facet Suhitha, Sivasubramanian
Srinivasan, Thothadri
Rajesh, Raju
Raghunathan, Raghavachary
Velmurugan, Devadasan
author_sort Suhitha, Sivasubramanian
collection PubMed
description In the title compound, C(37)H(34)N(2)O(7), both pyrrolidine rings adopt envelope conformations. The β-lactam ring is close to planar (r.m.s. deviation = 0.0395 Å) and makes a dihedral angle of 83.35 (15)° with the furan ring. The O atom attached to the β-lactam ring deviates by 0.187 (2) Å from the mean plane of the ring. The β-lactam ring makes dihedral angles of 14.90 (15) and 27.72 (17)° with the meth­oxy­phenyl and phenyl rings, respectively. The crystal packing features C—H⋯O hydrogen bonds.
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spelling pubmed-35889332013-03-08 Methyl 12-hydroxy-10-[1-(4-meth­oxy­phen­yl)-2-oxo-3-phen­oxy­azetidin-4-yl]-11-oxa-3-aza­hexa­cyclo­[11.7.1.0(2,9).0(2,12).0(3,7).0(17,21)]henicosa-1(20),13,15,17(21),18-penta­ene-9-carboxyl­ate Suhitha, Sivasubramanian Srinivasan, Thothadri Rajesh, Raju Raghunathan, Raghavachary Velmurugan, Devadasan Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title compound, C(37)H(34)N(2)O(7), both pyrrolidine rings adopt envelope conformations. The β-lactam ring is close to planar (r.m.s. deviation = 0.0395 Å) and makes a dihedral angle of 83.35 (15)° with the furan ring. The O atom attached to the β-lactam ring deviates by 0.187 (2) Å from the mean plane of the ring. The β-lactam ring makes dihedral angles of 14.90 (15) and 27.72 (17)° with the meth­oxy­phenyl and phenyl rings, respectively. The crystal packing features C—H⋯O hydrogen bonds. International Union of Crystallography 2012-11-10 /pmc/articles/PMC3588933/ /pubmed/23476169 http://dx.doi.org/10.1107/S1600536812045795 Text en © Suhitha et al. 2012 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Suhitha, Sivasubramanian
Srinivasan, Thothadri
Rajesh, Raju
Raghunathan, Raghavachary
Velmurugan, Devadasan
Methyl 12-hydroxy-10-[1-(4-meth­oxy­phen­yl)-2-oxo-3-phen­oxy­azetidin-4-yl]-11-oxa-3-aza­hexa­cyclo­[11.7.1.0(2,9).0(2,12).0(3,7).0(17,21)]henicosa-1(20),13,15,17(21),18-penta­ene-9-carboxyl­ate
title Methyl 12-hydroxy-10-[1-(4-meth­oxy­phen­yl)-2-oxo-3-phen­oxy­azetidin-4-yl]-11-oxa-3-aza­hexa­cyclo­[11.7.1.0(2,9).0(2,12).0(3,7).0(17,21)]henicosa-1(20),13,15,17(21),18-penta­ene-9-carboxyl­ate
title_full Methyl 12-hydroxy-10-[1-(4-meth­oxy­phen­yl)-2-oxo-3-phen­oxy­azetidin-4-yl]-11-oxa-3-aza­hexa­cyclo­[11.7.1.0(2,9).0(2,12).0(3,7).0(17,21)]henicosa-1(20),13,15,17(21),18-penta­ene-9-carboxyl­ate
title_fullStr Methyl 12-hydroxy-10-[1-(4-meth­oxy­phen­yl)-2-oxo-3-phen­oxy­azetidin-4-yl]-11-oxa-3-aza­hexa­cyclo­[11.7.1.0(2,9).0(2,12).0(3,7).0(17,21)]henicosa-1(20),13,15,17(21),18-penta­ene-9-carboxyl­ate
title_full_unstemmed Methyl 12-hydroxy-10-[1-(4-meth­oxy­phen­yl)-2-oxo-3-phen­oxy­azetidin-4-yl]-11-oxa-3-aza­hexa­cyclo­[11.7.1.0(2,9).0(2,12).0(3,7).0(17,21)]henicosa-1(20),13,15,17(21),18-penta­ene-9-carboxyl­ate
title_short Methyl 12-hydroxy-10-[1-(4-meth­oxy­phen­yl)-2-oxo-3-phen­oxy­azetidin-4-yl]-11-oxa-3-aza­hexa­cyclo­[11.7.1.0(2,9).0(2,12).0(3,7).0(17,21)]henicosa-1(20),13,15,17(21),18-penta­ene-9-carboxyl­ate
title_sort methyl 12-hydroxy-10-[1-(4-meth­oxy­phen­yl)-2-oxo-3-phen­oxy­azetidin-4-yl]-11-oxa-3-aza­hexa­cyclo­[11.7.1.0(2,9).0(2,12).0(3,7).0(17,21)]henicosa-1(20),13,15,17(21),18-penta­ene-9-carboxyl­ate
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588933/
https://www.ncbi.nlm.nih.gov/pubmed/23476169
http://dx.doi.org/10.1107/S1600536812045795
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