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(S,S,S,S)-Nebivolol hydrochloride hemihydrate
The asymmetric unit of the title hydrated salt, C(22)H(26)F(2)NO(4) (+)·Cl(−)·0.5H(2)O, consists of an (S,S,S,S)-nebivolol {nebivol = bis[2-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-hydroxyethyl]ammonium} cation, a chloride anion and a half-occupancy water molecule. The dihedral angle betwe...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588952/ https://www.ncbi.nlm.nih.gov/pubmed/23476188 http://dx.doi.org/10.1107/S1600536812045813 |
| Sumario: | The asymmetric unit of the title hydrated salt, C(22)H(26)F(2)NO(4) (+)·Cl(−)·0.5H(2)O, consists of an (S,S,S,S)-nebivolol {nebivol = bis[2-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-hydroxyethyl]ammonium} cation, a chloride anion and a half-occupancy water molecule. The dihedral angle between the mean planes of the benzene rings is 50.34 (12)°. The pyran rings adopt half-chair conformations. The crystal packing features O—H⋯O hydrogen bonds and weak N—H⋯Cl, O—H⋯Cl, and O—H⋯Cl interactions, producing layers along (010). |
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