Morphine hydro­chloride anhydrate

In the title mol­ecular salt [systematic name: (5α,6α)-7,8-didehydro-4,5-ep­oxy-17-methyl­morphinan-3,6-diol hydro­chloride], C(17)H(20)NO(3) (+)·Cl(−), the conformation of the morphinium ion is in agreement with the characteristics of the previously reported morphine forms [for example, Gylbert (19...

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Detalles Bibliográficos
Autores principales: Gelbrich, Thomas, Braun, Doris E., Griesser, Ulrich J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2012
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588957/
https://www.ncbi.nlm.nih.gov/pubmed/23476193
http://dx.doi.org/10.1107/S1600536812046405
Descripción
Sumario:In the title mol­ecular salt [systematic name: (5α,6α)-7,8-didehydro-4,5-ep­oxy-17-methyl­morphinan-3,6-diol hydro­chloride], C(17)H(20)NO(3) (+)·Cl(−), the conformation of the morphinium ion is in agreement with the characteristics of the previously reported morphine forms [for example, Gylbert (1973 ▶). Acta Cryst. B29, 1630–1635]. In the crystal, the cations and chloride anions are linked into a helical chain propagating parallel to the b-axis direction by N—H⋯Cl and O—H⋯Cl hydrogen bonds. The title salt and the morphine monohydrate [Bye (1976 ▶) Acta Chem. Scand. 30, 549–554] display very similar one-dimensional packing modes of their morphine components.

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