Morphine hydro­chloride anhydrate

In the title mol­ecular salt [systematic name: (5α,6α)-7,8-didehydro-4,5-ep­oxy-17-methyl­morphinan-3,6-diol hydro­chloride], C(17)H(20)NO(3) (+)·Cl(−), the conformation of the morphinium ion is in agreement with the characteristics of the previously reported morphine forms [for example, Gylbert (19...

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Detalles Bibliográficos
Autores principales: Gelbrich, Thomas, Braun, Doris E., Griesser, Ulrich J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2012
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588957/
https://www.ncbi.nlm.nih.gov/pubmed/23476193
http://dx.doi.org/10.1107/S1600536812046405
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author Gelbrich, Thomas
Braun, Doris E.
Griesser, Ulrich J.
author_facet Gelbrich, Thomas
Braun, Doris E.
Griesser, Ulrich J.
author_sort Gelbrich, Thomas
collection PubMed
description In the title mol­ecular salt [systematic name: (5α,6α)-7,8-didehydro-4,5-ep­oxy-17-methyl­morphinan-3,6-diol hydro­chloride], C(17)H(20)NO(3) (+)·Cl(−), the conformation of the morphinium ion is in agreement with the characteristics of the previously reported morphine forms [for example, Gylbert (1973 ▶). Acta Cryst. B29, 1630–1635]. In the crystal, the cations and chloride anions are linked into a helical chain propagating parallel to the b-axis direction by N—H⋯Cl and O—H⋯Cl hydrogen bonds. The title salt and the morphine monohydrate [Bye (1976 ▶) Acta Chem. Scand. 30, 549–554] display very similar one-dimensional packing modes of their morphine components.
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spelling pubmed-35889572013-03-08 Morphine hydro­chloride anhydrate Gelbrich, Thomas Braun, Doris E. Griesser, Ulrich J. Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title mol­ecular salt [systematic name: (5α,6α)-7,8-didehydro-4,5-ep­oxy-17-methyl­morphinan-3,6-diol hydro­chloride], C(17)H(20)NO(3) (+)·Cl(−), the conformation of the morphinium ion is in agreement with the characteristics of the previously reported morphine forms [for example, Gylbert (1973 ▶). Acta Cryst. B29, 1630–1635]. In the crystal, the cations and chloride anions are linked into a helical chain propagating parallel to the b-axis direction by N—H⋯Cl and O—H⋯Cl hydrogen bonds. The title salt and the morphine monohydrate [Bye (1976 ▶) Acta Chem. Scand. 30, 549–554] display very similar one-dimensional packing modes of their morphine components. International Union of Crystallography 2012-11-17 /pmc/articles/PMC3588957/ /pubmed/23476193 http://dx.doi.org/10.1107/S1600536812046405 Text en © Gelbrich et al. 2012 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Gelbrich, Thomas
Braun, Doris E.
Griesser, Ulrich J.
Morphine hydro­chloride anhydrate
title Morphine hydro­chloride anhydrate
title_full Morphine hydro­chloride anhydrate
title_fullStr Morphine hydro­chloride anhydrate
title_full_unstemmed Morphine hydro­chloride anhydrate
title_short Morphine hydro­chloride anhydrate
title_sort morphine hydro­chloride anhydrate
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588957/
https://www.ncbi.nlm.nih.gov/pubmed/23476193
http://dx.doi.org/10.1107/S1600536812046405
work_keys_str_mv AT gelbrichthomas morphinehydrochlorideanhydrate
AT braundorise morphinehydrochlorideanhydrate
AT griesserulrichj morphinehydrochlorideanhydrate

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