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5-[(3,5-Dichloroanilino)methyl]-N-(3,5-dichlorophenyl)-6-methyl-2-phenylpyrimidin-4-amine
In the title compound, C(24)H(18)Cl(4)N(4), the pyrimidine ring makes dihedral angles of 19.1 (2), 4.1 (2) and 67.5 (2)°, respectively, with phenyl and two benzene rings, and the molecular conformation is stabilized by an intramolecular N—H⋯N hydrogen bond closing a six-membered ring with an S(6)...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588999/ https://www.ncbi.nlm.nih.gov/pubmed/23476235 http://dx.doi.org/10.1107/S160053681204665X |
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author | Cieplik, Jerzy Pluta, Janusz Bryndal, Iwona Lis, Tadeusz |
author_facet | Cieplik, Jerzy Pluta, Janusz Bryndal, Iwona Lis, Tadeusz |
author_sort | Cieplik, Jerzy |
collection | PubMed |
description | In the title compound, C(24)H(18)Cl(4)N(4), the pyrimidine ring makes dihedral angles of 19.1 (2), 4.1 (2) and 67.5 (2)°, respectively, with phenyl and two benzene rings, and the molecular conformation is stabilized by an intramolecular N—H⋯N hydrogen bond closing a six-membered ring with an S(6) motif. In the crystal, a pair of intermolecular N—H⋯N hydrogen bonds connect two molecules, forming inversion dimers with R (2) (2)(12) motifs. C—H⋯π interactions links the dimers into a chain running along the a-axis direction. There are also π–π stacking interactions [centroid–centroid distance = 3.666 (4) Å] between the benzene rings of adjacent chains. |
format | Online Article Text |
id | pubmed-3588999 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-35889992013-03-08 5-[(3,5-Dichloroanilino)methyl]-N-(3,5-dichlorophenyl)-6-methyl-2-phenylpyrimidin-4-amine Cieplik, Jerzy Pluta, Janusz Bryndal, Iwona Lis, Tadeusz Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title compound, C(24)H(18)Cl(4)N(4), the pyrimidine ring makes dihedral angles of 19.1 (2), 4.1 (2) and 67.5 (2)°, respectively, with phenyl and two benzene rings, and the molecular conformation is stabilized by an intramolecular N—H⋯N hydrogen bond closing a six-membered ring with an S(6) motif. In the crystal, a pair of intermolecular N—H⋯N hydrogen bonds connect two molecules, forming inversion dimers with R (2) (2)(12) motifs. C—H⋯π interactions links the dimers into a chain running along the a-axis direction. There are also π–π stacking interactions [centroid–centroid distance = 3.666 (4) Å] between the benzene rings of adjacent chains. International Union of Crystallography 2012-11-24 /pmc/articles/PMC3588999/ /pubmed/23476235 http://dx.doi.org/10.1107/S160053681204665X Text en © Cieplik et al. 2012 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Organic Papers Cieplik, Jerzy Pluta, Janusz Bryndal, Iwona Lis, Tadeusz 5-[(3,5-Dichloroanilino)methyl]-N-(3,5-dichlorophenyl)-6-methyl-2-phenylpyrimidin-4-amine |
title | 5-[(3,5-Dichloroanilino)methyl]-N-(3,5-dichlorophenyl)-6-methyl-2-phenylpyrimidin-4-amine |
title_full | 5-[(3,5-Dichloroanilino)methyl]-N-(3,5-dichlorophenyl)-6-methyl-2-phenylpyrimidin-4-amine |
title_fullStr | 5-[(3,5-Dichloroanilino)methyl]-N-(3,5-dichlorophenyl)-6-methyl-2-phenylpyrimidin-4-amine |
title_full_unstemmed | 5-[(3,5-Dichloroanilino)methyl]-N-(3,5-dichlorophenyl)-6-methyl-2-phenylpyrimidin-4-amine |
title_short | 5-[(3,5-Dichloroanilino)methyl]-N-(3,5-dichlorophenyl)-6-methyl-2-phenylpyrimidin-4-amine |
title_sort | 5-[(3,5-dichloroanilino)methyl]-n-(3,5-dichlorophenyl)-6-methyl-2-phenylpyrimidin-4-amine |
topic | Organic Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588999/ https://www.ncbi.nlm.nih.gov/pubmed/23476235 http://dx.doi.org/10.1107/S160053681204665X |
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