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Steroid Induced Ocular Hypertension Following Myopic Photorefractive Keratectomy
PURPOSE: To determine the incidence of steroid induced ocular hypertension following myopic photorefractive keratectomy (PRK). METHODS: Myopic PRK was performed on 506 eyes of 269 patients. Preoperatively, spherical equivalent refractive error ranged from −1.00 to −5.00 diopters (D) and cylinder was...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Ophthalmic Research Center
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589213/ https://www.ncbi.nlm.nih.gov/pubmed/23479521 |
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author | Javadi, Mohammad-Ali Mirbabaei-Ghafghazi, Firooz Mirzade, Monirsadat Yazdani, Shahin Yaseri, Mehdi |
author_facet | Javadi, Mohammad-Ali Mirbabaei-Ghafghazi, Firooz Mirzade, Monirsadat Yazdani, Shahin Yaseri, Mehdi |
author_sort | Javadi, Mohammad-Ali |
collection | PubMed |
description | PURPOSE: To determine the incidence of steroid induced ocular hypertension following myopic photorefractive keratectomy (PRK). METHODS: Myopic PRK was performed on 506 eyes of 269 patients. Preoperatively, spherical equivalent refractive error ranged from −1.00 to −5.00 diopters (D) and cylinder was less than 4 D. Baseline intraocular pressure (IOP) before PRK and at different time intervals after the procedure was measured by Goldmann applanation tonometry. IOP readings were corrected according to central corneal thickness as measured by Orbscan pachymetry. For the purpose of the study, corrected IOP >21 mmHg was considered as ocular hypertension. RESULTS: Ocular hypertension developed in 40 (7.9%) eyes overall, which occurred in 16 eyes (40%) 2–3 weeks postoperatively (mean IOP=23.5±3.0mmHg), in 20 eyes (50%) after 4–6 weeks (mean IOP=25.1±4.2 mmHg) and in 4 eyes (10%) 8–12 weeks following PRK (mean IOP=29.0±3.1 mmHg). There was no correlation between the level of IOP rise and preoperative spherical equivalent refractive error. IOP recovered to normal in all eyes after discontinuation of topical steroids and initiation of anti-glaucoma medications. Mean duration of IOP normalization was 28.5±27.7 (range 7–108 ) days and no instance of steroid-induced glaucoma was observed in any patient. CONCLUSION: Topical steroids may cause ocular hypertension following PRK. Early detec-tion, prompt treatment and close follow-up are recommended. We suggest measuring IOP in post-PRK patients no later than 10 to 14 days after initiation of corticosteroid treatment. |
format | Online Article Text |
id | pubmed-3589213 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Ophthalmic Research Center |
record_format | MEDLINE/PubMed |
spelling | pubmed-35892132013-03-11 Steroid Induced Ocular Hypertension Following Myopic Photorefractive Keratectomy Javadi, Mohammad-Ali Mirbabaei-Ghafghazi, Firooz Mirzade, Monirsadat Yazdani, Shahin Yaseri, Mehdi J Ophthalmic Vis Res Original Article PURPOSE: To determine the incidence of steroid induced ocular hypertension following myopic photorefractive keratectomy (PRK). METHODS: Myopic PRK was performed on 506 eyes of 269 patients. Preoperatively, spherical equivalent refractive error ranged from −1.00 to −5.00 diopters (D) and cylinder was less than 4 D. Baseline intraocular pressure (IOP) before PRK and at different time intervals after the procedure was measured by Goldmann applanation tonometry. IOP readings were corrected according to central corneal thickness as measured by Orbscan pachymetry. For the purpose of the study, corrected IOP >21 mmHg was considered as ocular hypertension. RESULTS: Ocular hypertension developed in 40 (7.9%) eyes overall, which occurred in 16 eyes (40%) 2–3 weeks postoperatively (mean IOP=23.5±3.0mmHg), in 20 eyes (50%) after 4–6 weeks (mean IOP=25.1±4.2 mmHg) and in 4 eyes (10%) 8–12 weeks following PRK (mean IOP=29.0±3.1 mmHg). There was no correlation between the level of IOP rise and preoperative spherical equivalent refractive error. IOP recovered to normal in all eyes after discontinuation of topical steroids and initiation of anti-glaucoma medications. Mean duration of IOP normalization was 28.5±27.7 (range 7–108 ) days and no instance of steroid-induced glaucoma was observed in any patient. CONCLUSION: Topical steroids may cause ocular hypertension following PRK. Early detec-tion, prompt treatment and close follow-up are recommended. We suggest measuring IOP in post-PRK patients no later than 10 to 14 days after initiation of corticosteroid treatment. Ophthalmic Research Center 2008-01 /pmc/articles/PMC3589213/ /pubmed/23479521 Text en © 2008 Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. |
spellingShingle | Original Article Javadi, Mohammad-Ali Mirbabaei-Ghafghazi, Firooz Mirzade, Monirsadat Yazdani, Shahin Yaseri, Mehdi Steroid Induced Ocular Hypertension Following Myopic Photorefractive Keratectomy |
title | Steroid Induced Ocular Hypertension Following Myopic Photorefractive Keratectomy |
title_full | Steroid Induced Ocular Hypertension Following Myopic Photorefractive Keratectomy |
title_fullStr | Steroid Induced Ocular Hypertension Following Myopic Photorefractive Keratectomy |
title_full_unstemmed | Steroid Induced Ocular Hypertension Following Myopic Photorefractive Keratectomy |
title_short | Steroid Induced Ocular Hypertension Following Myopic Photorefractive Keratectomy |
title_sort | steroid induced ocular hypertension following myopic photorefractive keratectomy |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589213/ https://www.ncbi.nlm.nih.gov/pubmed/23479521 |
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