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Steroid Induced Ocular Hypertension Following Myopic Photorefractive Keratectomy

PURPOSE: To determine the incidence of steroid induced ocular hypertension following myopic photorefractive keratectomy (PRK). METHODS: Myopic PRK was performed on 506 eyes of 269 patients. Preoperatively, spherical equivalent refractive error ranged from −1.00 to −5.00 diopters (D) and cylinder was...

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Autores principales: Javadi, Mohammad-Ali, Mirbabaei-Ghafghazi, Firooz, Mirzade, Monirsadat, Yazdani, Shahin, Yaseri, Mehdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ophthalmic Research Center 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589213/
https://www.ncbi.nlm.nih.gov/pubmed/23479521
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author Javadi, Mohammad-Ali
Mirbabaei-Ghafghazi, Firooz
Mirzade, Monirsadat
Yazdani, Shahin
Yaseri, Mehdi
author_facet Javadi, Mohammad-Ali
Mirbabaei-Ghafghazi, Firooz
Mirzade, Monirsadat
Yazdani, Shahin
Yaseri, Mehdi
author_sort Javadi, Mohammad-Ali
collection PubMed
description PURPOSE: To determine the incidence of steroid induced ocular hypertension following myopic photorefractive keratectomy (PRK). METHODS: Myopic PRK was performed on 506 eyes of 269 patients. Preoperatively, spherical equivalent refractive error ranged from −1.00 to −5.00 diopters (D) and cylinder was less than 4 D. Baseline intraocular pressure (IOP) before PRK and at different time intervals after the procedure was measured by Goldmann applanation tonometry. IOP readings were corrected according to central corneal thickness as measured by Orbscan pachymetry. For the purpose of the study, corrected IOP >21 mmHg was considered as ocular hypertension. RESULTS: Ocular hypertension developed in 40 (7.9%) eyes overall, which occurred in 16 eyes (40%) 2–3 weeks postoperatively (mean IOP=23.5±3.0mmHg), in 20 eyes (50%) after 4–6 weeks (mean IOP=25.1±4.2 mmHg) and in 4 eyes (10%) 8–12 weeks following PRK (mean IOP=29.0±3.1 mmHg). There was no correlation between the level of IOP rise and preoperative spherical equivalent refractive error. IOP recovered to normal in all eyes after discontinuation of topical steroids and initiation of anti-glaucoma medications. Mean duration of IOP normalization was 28.5±27.7 (range 7–108 ) days and no instance of steroid-induced glaucoma was observed in any patient. CONCLUSION: Topical steroids may cause ocular hypertension following PRK. Early detec-tion, prompt treatment and close follow-up are recommended. We suggest measuring IOP in post-PRK patients no later than 10 to 14 days after initiation of corticosteroid treatment.
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spelling pubmed-35892132013-03-11 Steroid Induced Ocular Hypertension Following Myopic Photorefractive Keratectomy Javadi, Mohammad-Ali Mirbabaei-Ghafghazi, Firooz Mirzade, Monirsadat Yazdani, Shahin Yaseri, Mehdi J Ophthalmic Vis Res Original Article PURPOSE: To determine the incidence of steroid induced ocular hypertension following myopic photorefractive keratectomy (PRK). METHODS: Myopic PRK was performed on 506 eyes of 269 patients. Preoperatively, spherical equivalent refractive error ranged from −1.00 to −5.00 diopters (D) and cylinder was less than 4 D. Baseline intraocular pressure (IOP) before PRK and at different time intervals after the procedure was measured by Goldmann applanation tonometry. IOP readings were corrected according to central corneal thickness as measured by Orbscan pachymetry. For the purpose of the study, corrected IOP >21 mmHg was considered as ocular hypertension. RESULTS: Ocular hypertension developed in 40 (7.9%) eyes overall, which occurred in 16 eyes (40%) 2–3 weeks postoperatively (mean IOP=23.5±3.0mmHg), in 20 eyes (50%) after 4–6 weeks (mean IOP=25.1±4.2 mmHg) and in 4 eyes (10%) 8–12 weeks following PRK (mean IOP=29.0±3.1 mmHg). There was no correlation between the level of IOP rise and preoperative spherical equivalent refractive error. IOP recovered to normal in all eyes after discontinuation of topical steroids and initiation of anti-glaucoma medications. Mean duration of IOP normalization was 28.5±27.7 (range 7–108 ) days and no instance of steroid-induced glaucoma was observed in any patient. CONCLUSION: Topical steroids may cause ocular hypertension following PRK. Early detec-tion, prompt treatment and close follow-up are recommended. We suggest measuring IOP in post-PRK patients no later than 10 to 14 days after initiation of corticosteroid treatment. Ophthalmic Research Center 2008-01 /pmc/articles/PMC3589213/ /pubmed/23479521 Text en © 2008 Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Javadi, Mohammad-Ali
Mirbabaei-Ghafghazi, Firooz
Mirzade, Monirsadat
Yazdani, Shahin
Yaseri, Mehdi
Steroid Induced Ocular Hypertension Following Myopic Photorefractive Keratectomy
title Steroid Induced Ocular Hypertension Following Myopic Photorefractive Keratectomy
title_full Steroid Induced Ocular Hypertension Following Myopic Photorefractive Keratectomy
title_fullStr Steroid Induced Ocular Hypertension Following Myopic Photorefractive Keratectomy
title_full_unstemmed Steroid Induced Ocular Hypertension Following Myopic Photorefractive Keratectomy
title_short Steroid Induced Ocular Hypertension Following Myopic Photorefractive Keratectomy
title_sort steroid induced ocular hypertension following myopic photorefractive keratectomy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589213/
https://www.ncbi.nlm.nih.gov/pubmed/23479521
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