Malate and Fumarate Extend Lifespan in Caenorhabditis elegans

Malate, the tricarboxylic acid (TCA) cycle metabolite, increased lifespan and thermotolerance in the nematode C. elegans. Malate can be synthesized from fumarate by the enzyme fumarase and further oxidized to oxaloacetate by malate dehydrogenase with the accompanying reduction of NAD. Addition of fu...

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Detalles Bibliográficos
Autores principales: Edwards, Clare B., Copes, Neil, Brito, Andres G., Canfield, John, Bradshaw, Patrick C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589421/
https://www.ncbi.nlm.nih.gov/pubmed/23472183
http://dx.doi.org/10.1371/journal.pone.0058345

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