SPLUNC1 Regulates Cell Progression and Apoptosis through the miR-141-PTEN/p27 Pathway, but Is Hindered by LMP1

Little is known about the role of the host defensive protein short palate, lung and nasal epithelium clone 1 (SPLUNC1) in the carcinogenesis of nasopharyngeal carcinoma (NPC). Here we report that SPLUNC1 plays a role at a very early stage of NPC carcinogenesis. SPLUNC1 regulates NPC cell proliferati...

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Detalles Bibliográficos
Autores principales: Chen, Pan, Guo, Xiaofang, Zhou, Houde, Zhang, Wenling, Zeng, Zhaoyang, Liao, Qianjin, Li, Xiayu, Xiang, Bo, Yang, Jianbo, Ma, Jian, Zhou, Ming, Peng, Shuping, Xiang, Juanjuan, Li, Xiaoling, LE, Colvin Wanshura, Xiong, Wei, McCarthy, James B., Li, Guiyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589440/
https://www.ncbi.nlm.nih.gov/pubmed/23472073
http://dx.doi.org/10.1371/journal.pone.0056929
Descripción
Sumario:Little is known about the role of the host defensive protein short palate, lung and nasal epithelium clone 1 (SPLUNC1) in the carcinogenesis of nasopharyngeal carcinoma (NPC). Here we report that SPLUNC1 plays a role at a very early stage of NPC carcinogenesis. SPLUNC1 regulates NPC cell proliferation, differentiation and apoptosis through miR-141, which in turn regulates PTEN and p27 expression. This signaling axis is negatively regulated by the EBV-coded gene LMP1. Therefore we propose that SPLUNC1 suppresses NPC tumor formation and its inhibition by LMP1 provides a route for NPC tumorigenesis.

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