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SPLUNC1 Regulates Cell Progression and Apoptosis through the miR-141-PTEN/p27 Pathway, but Is Hindered by LMP1
Little is known about the role of the host defensive protein short palate, lung and nasal epithelium clone 1 (SPLUNC1) in the carcinogenesis of nasopharyngeal carcinoma (NPC). Here we report that SPLUNC1 plays a role at a very early stage of NPC carcinogenesis. SPLUNC1 regulates NPC cell proliferati...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589440/ https://www.ncbi.nlm.nih.gov/pubmed/23472073 http://dx.doi.org/10.1371/journal.pone.0056929 |
| _version_ | 1782261734696812544 |
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| author | Chen, Pan Guo, Xiaofang Zhou, Houde Zhang, Wenling Zeng, Zhaoyang Liao, Qianjin Li, Xiayu Xiang, Bo Yang, Jianbo Ma, Jian Zhou, Ming Peng, Shuping Xiang, Juanjuan Li, Xiaoling LE, Colvin Wanshura Xiong, Wei McCarthy, James B. Li, Guiyuan |
| author_facet | Chen, Pan Guo, Xiaofang Zhou, Houde Zhang, Wenling Zeng, Zhaoyang Liao, Qianjin Li, Xiayu Xiang, Bo Yang, Jianbo Ma, Jian Zhou, Ming Peng, Shuping Xiang, Juanjuan Li, Xiaoling LE, Colvin Wanshura Xiong, Wei McCarthy, James B. Li, Guiyuan |
| author_sort | Chen, Pan |
| collection | PubMed |
| description | Little is known about the role of the host defensive protein short palate, lung and nasal epithelium clone 1 (SPLUNC1) in the carcinogenesis of nasopharyngeal carcinoma (NPC). Here we report that SPLUNC1 plays a role at a very early stage of NPC carcinogenesis. SPLUNC1 regulates NPC cell proliferation, differentiation and apoptosis through miR-141, which in turn regulates PTEN and p27 expression. This signaling axis is negatively regulated by the EBV-coded gene LMP1. Therefore we propose that SPLUNC1 suppresses NPC tumor formation and its inhibition by LMP1 provides a route for NPC tumorigenesis. |
| format | Online Article Text |
| id | pubmed-3589440 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| publisher | Public Library of Science |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-35894402013-03-07 SPLUNC1 Regulates Cell Progression and Apoptosis through the miR-141-PTEN/p27 Pathway, but Is Hindered by LMP1 Chen, Pan Guo, Xiaofang Zhou, Houde Zhang, Wenling Zeng, Zhaoyang Liao, Qianjin Li, Xiayu Xiang, Bo Yang, Jianbo Ma, Jian Zhou, Ming Peng, Shuping Xiang, Juanjuan Li, Xiaoling LE, Colvin Wanshura Xiong, Wei McCarthy, James B. Li, Guiyuan PLoS One Research Article Little is known about the role of the host defensive protein short palate, lung and nasal epithelium clone 1 (SPLUNC1) in the carcinogenesis of nasopharyngeal carcinoma (NPC). Here we report that SPLUNC1 plays a role at a very early stage of NPC carcinogenesis. SPLUNC1 regulates NPC cell proliferation, differentiation and apoptosis through miR-141, which in turn regulates PTEN and p27 expression. This signaling axis is negatively regulated by the EBV-coded gene LMP1. Therefore we propose that SPLUNC1 suppresses NPC tumor formation and its inhibition by LMP1 provides a route for NPC tumorigenesis. Public Library of Science 2013-03-05 /pmc/articles/PMC3589440/ /pubmed/23472073 http://dx.doi.org/10.1371/journal.pone.0056929 Text en © 2013 Chen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
| spellingShingle | Research Article Chen, Pan Guo, Xiaofang Zhou, Houde Zhang, Wenling Zeng, Zhaoyang Liao, Qianjin Li, Xiayu Xiang, Bo Yang, Jianbo Ma, Jian Zhou, Ming Peng, Shuping Xiang, Juanjuan Li, Xiaoling LE, Colvin Wanshura Xiong, Wei McCarthy, James B. Li, Guiyuan SPLUNC1 Regulates Cell Progression and Apoptosis through the miR-141-PTEN/p27 Pathway, but Is Hindered by LMP1 |
| title | SPLUNC1 Regulates Cell Progression and Apoptosis through the miR-141-PTEN/p27 Pathway, but Is Hindered by LMP1 |
| title_full | SPLUNC1 Regulates Cell Progression and Apoptosis through the miR-141-PTEN/p27 Pathway, but Is Hindered by LMP1 |
| title_fullStr | SPLUNC1 Regulates Cell Progression and Apoptosis through the miR-141-PTEN/p27 Pathway, but Is Hindered by LMP1 |
| title_full_unstemmed | SPLUNC1 Regulates Cell Progression and Apoptosis through the miR-141-PTEN/p27 Pathway, but Is Hindered by LMP1 |
| title_short | SPLUNC1 Regulates Cell Progression and Apoptosis through the miR-141-PTEN/p27 Pathway, but Is Hindered by LMP1 |
| title_sort | splunc1 regulates cell progression and apoptosis through the mir-141-pten/p27 pathway, but is hindered by lmp1 |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589440/ https://www.ncbi.nlm.nih.gov/pubmed/23472073 http://dx.doi.org/10.1371/journal.pone.0056929 |
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