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Strain Typing of Classical Scrapie by Transgenic Mouse Bioassay Using Protein Misfolding Cyclic Amplification to Replace Primary Passage
According to traditional murine bioassay methodology, prions must be serially passaged within a new host before a stable phenotype, and therefore a strain, can be assigned. Prions often transmit with difficulty from one species to another; a property termed the transmission barrier. Transgenic mouse...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589467/ https://www.ncbi.nlm.nih.gov/pubmed/23472112 http://dx.doi.org/10.1371/journal.pone.0057851 |