Somatic neurofibromatosis type 1 (NF1) inactivation characterizes NF1-associated pilocytic astrocytoma

Low-grade brain tumors (pilocytic astrocytomas) arising in the neurofibromatosis type 1 (NF1) inherited cancer predisposition syndrome are hypothesized to result from a combination of germline and acquired somatic NF1 tumor suppressor gene mutations. However, genetically engineered mice (GEM) in whi...

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Detalles Bibliográficos
Autores principales: Gutmann, David H., McLellan, Michael D., Hussain, Ibrahim, Wallis, John W., Fulton, Lucinda L., Fulton, Robert S., Magrini, Vincent, Demeter, Ryan, Wylie, Todd, Kandoth, Cyriac, Leonard, Jeffrey R., Guha, Abhijit, Miller, Christopher A., Ding, Li, Mardis, Elaine R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589532/
https://www.ncbi.nlm.nih.gov/pubmed/23222849
http://dx.doi.org/10.1101/gr.142604.112

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