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CHD1L Is a Marker for Poor Prognosis of Hepatocellular Carcinoma after Surgical Resection
BACKGROUND: The gene for chromodomain helicase/ATPase DNA binding protein 1-like (CHD1L) was recently identified as a target oncogene within the 1q21 amplicon, which occurs in 46% to 86% of primary hepatocellular carcinoma (HCC) cases. However, the prognostic significance of CHD1L in HCC remains unc...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Pathologists and The Korean Society for Cytopathology
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589617/ https://www.ncbi.nlm.nih.gov/pubmed/23482400 http://dx.doi.org/10.4132/KoreanJPathol.2013.47.1.9 |
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author | Hyeon, Jiyeon Ahn, Soomin Park, Cheol-Keun |
author_facet | Hyeon, Jiyeon Ahn, Soomin Park, Cheol-Keun |
author_sort | Hyeon, Jiyeon |
collection | PubMed |
description | BACKGROUND: The gene for chromodomain helicase/ATPase DNA binding protein 1-like (CHD1L) was recently identified as a target oncogene within the 1q21 amplicon, which occurs in 46% to 86% of primary hepatocellular carcinoma (HCC) cases. However, the prognostic significance of CHD1L in HCC remains uncertain. In this study, we investigated the roles of CHD1L in the prognosis of HCC. METHODS: We investigated the expressions of CHD1L in tumor tissue microarrays of 281 primary HCC patients who underwent surgical resection using immunohistochemistry. Prognostic factors of HCC were examined by univariate and multivariate analyses. The median follow-up period was 75.6 months. RESULTS: CHD1L expression was observed in 48 of the 281 HCCs (17.1%). CHD1L expression was associated with a younger age (p=0.033), higher Edmondson grade (p=0.019), microvascular invasion (p<0.001), major portal vein invasion (p=0.037), higher American Joint Committee on Cancer T stage (p=0.001), lower albumin level (p=0.047), and higher α-fetoprotein level (p=0.002). Multivariate analyses revealed that CHD1L expression (p=0.027), Edmondson grade III (p=0.034), and higher Barcelona Clinic Liver Cancer stage (p<0.001) were independent predictors of shorter disease-free survival. CONCLUSIONS: CHD1L expression might be a prognostic marker of shorter disease-free survival in HCC patients after surgical resection. |
format | Online Article Text |
id | pubmed-3589617 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Korean Society of Pathologists and The Korean Society for Cytopathology |
record_format | MEDLINE/PubMed |
spelling | pubmed-35896172013-03-11 CHD1L Is a Marker for Poor Prognosis of Hepatocellular Carcinoma after Surgical Resection Hyeon, Jiyeon Ahn, Soomin Park, Cheol-Keun Korean J Pathol Original Article BACKGROUND: The gene for chromodomain helicase/ATPase DNA binding protein 1-like (CHD1L) was recently identified as a target oncogene within the 1q21 amplicon, which occurs in 46% to 86% of primary hepatocellular carcinoma (HCC) cases. However, the prognostic significance of CHD1L in HCC remains uncertain. In this study, we investigated the roles of CHD1L in the prognosis of HCC. METHODS: We investigated the expressions of CHD1L in tumor tissue microarrays of 281 primary HCC patients who underwent surgical resection using immunohistochemistry. Prognostic factors of HCC were examined by univariate and multivariate analyses. The median follow-up period was 75.6 months. RESULTS: CHD1L expression was observed in 48 of the 281 HCCs (17.1%). CHD1L expression was associated with a younger age (p=0.033), higher Edmondson grade (p=0.019), microvascular invasion (p<0.001), major portal vein invasion (p=0.037), higher American Joint Committee on Cancer T stage (p=0.001), lower albumin level (p=0.047), and higher α-fetoprotein level (p=0.002). Multivariate analyses revealed that CHD1L expression (p=0.027), Edmondson grade III (p=0.034), and higher Barcelona Clinic Liver Cancer stage (p<0.001) were independent predictors of shorter disease-free survival. CONCLUSIONS: CHD1L expression might be a prognostic marker of shorter disease-free survival in HCC patients after surgical resection. The Korean Society of Pathologists and The Korean Society for Cytopathology 2013-02 2013-02-25 /pmc/articles/PMC3589617/ /pubmed/23482400 http://dx.doi.org/10.4132/KoreanJPathol.2013.47.1.9 Text en © 2013 The Korean Society of Pathologists/The Korean Society for Cytopathology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Hyeon, Jiyeon Ahn, Soomin Park, Cheol-Keun CHD1L Is a Marker for Poor Prognosis of Hepatocellular Carcinoma after Surgical Resection |
title | CHD1L Is a Marker for Poor Prognosis of Hepatocellular Carcinoma after Surgical Resection |
title_full | CHD1L Is a Marker for Poor Prognosis of Hepatocellular Carcinoma after Surgical Resection |
title_fullStr | CHD1L Is a Marker for Poor Prognosis of Hepatocellular Carcinoma after Surgical Resection |
title_full_unstemmed | CHD1L Is a Marker for Poor Prognosis of Hepatocellular Carcinoma after Surgical Resection |
title_short | CHD1L Is a Marker for Poor Prognosis of Hepatocellular Carcinoma after Surgical Resection |
title_sort | chd1l is a marker for poor prognosis of hepatocellular carcinoma after surgical resection |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589617/ https://www.ncbi.nlm.nih.gov/pubmed/23482400 http://dx.doi.org/10.4132/KoreanJPathol.2013.47.1.9 |
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