Systematic repression of transcription factors reveals limited patterns of gene expression changes in ES cells

Networks of transcription factors (TFs) are thought to determine and maintain the identity of cells. Here we systematically repressed each of 100 TFs with shRNA and carried out global gene expression profiling in mouse embryonic stem (ES) cells. Unexpectedly, only the repression of a handful of TFs...

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Detalles Bibliográficos
Autores principales: Nishiyama, Akira, Sharov, Alexei A., Piao, Yulan, Amano, Misa, Amano, Tomokazu, Hoang, Hien G., Binder, Bernard Y., Tapnio, Richard, Bassey, Uwem, Malinou, Justin N., Correa-Cerro, Lina S., Yu, Hong, Xin, Li, Meyers, Emily, Zalzman, Michal, Nakatake, Yuhki, Stagg, Carole, Sharova, Lioudmila, Qian, Yong, Dudekula, Dawood, Sheer, Sarah, Cadet, Jean S., Hirata, Tetsuya, Yang, Hsih-Te, Goldberg, Ilya, Evans, Michele K., Longo, Dan L., Schlessinger, David, Ko, Minoru S. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589720/
https://www.ncbi.nlm.nih.gov/pubmed/23462645
http://dx.doi.org/10.1038/srep01390

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