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The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat

Human positive transcription elongation factor b (P-TEFb) phosphorylates RNA polymerase II and regulatory proteins to trigger elongation of many gene transcripts. The HIV-1 Tat protein selectively recruits P-TEFb as part of a super elongation complex (SEC) organized on a flexible AFF1 or AFF4 scaffo...

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Detalles Bibliográficos
Autores principales:	Schulze-Gahmen, Ursula, Upton, Heather, Birnberg, Andrew, Bao, Katherine, Chou, Seemay, Krogan, Nevan J, Zhou, Qiang, Alber, Tom
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2013
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589825/ https://www.ncbi.nlm.nih.gov/pubmed/23471103 http://dx.doi.org/10.7554/eLife.00327

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