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Whole-body diffusion-weighted magnetic resonance imaging at 3 Tesla for early assessment of treatment response in non-Hodgkin lymphoma: a pilot study
Objective: To evaluate 3 Tesla (T) whole-body diffusion-weighted magnetic resonance imaging (WB DWI) for early treatment assessment in aggressive non-Hodgkin lymphoma (NHL). Methods: Fourteen patients with NHL treated with standard chemotherapy underwent 3-T WB DWI before and 2 and 4 weeks during tr...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
e-Med
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589948/ https://www.ncbi.nlm.nih.gov/pubmed/23466737 http://dx.doi.org/10.1102/1470-7330.2013.0006 |
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author | De Paepe, Katja Bevernage, Charlotte De Keyzer, Frederik Wolter, Pascal Gheysens, Olivier Janssens, Ann Oyen, Raymond Verhoef, Gregor Vandecaveye, Vincent |
author_facet | De Paepe, Katja Bevernage, Charlotte De Keyzer, Frederik Wolter, Pascal Gheysens, Olivier Janssens, Ann Oyen, Raymond Verhoef, Gregor Vandecaveye, Vincent |
author_sort | De Paepe, Katja |
collection | PubMed |
description | Objective: To evaluate 3 Tesla (T) whole-body diffusion-weighted magnetic resonance imaging (WB DWI) for early treatment assessment in aggressive non-Hodgkin lymphoma (NHL). Methods: Fourteen patients with NHL treated with standard chemotherapy underwent 3-T WB DWI before and 2 and 4 weeks during treatment, using b-values of 0–1000 s/mm(2) from which the apparent diffusion coefficient (ADC) was calculated. Patient follow-up (average 20.3 months, range 15–23 months) was the reference standard. Volume and ADC changes between baseline and 2 weeks (Vratio(2w), ADCratio(2w)) and 4 weeks (Vratio(4w), ADCratio(4w)) of responding and non-responding lesions (lymph node and organ lesions) were compared using Mann–Whitney U tests. The per patient values of Vratio(N) and ADCratio(N) to predict progression-free survival were determined with a log-rank test. Results: Eight patients showed complete remission and 6 showed tumour progression. The ADCratio(2w) and ADCratio(4w) differed significantly in lesions showing tumour progression versus complete remission (ADCratio(2w) = 4 ± 21% versus 119 ± 68%; ADCratio(4w) = 18 ± 61% versus 155 ± 78%; both P < 0.0001); the Vratio(2w) and Vratio(4w) did not (P > 0.05). Per body region, the ADCratio(2w) showed a negative predictive value of 100% and positive predictive value of 86%. Per patient, the ADCratio(2w) and ADCratio(4w) correlated significantly with progression-free survival (P < 0.05). Conclusion: 3-T WB DWI with ADC quantification may enable early treatment assessment of aggressive NHL. |
format | Online Article Text |
id | pubmed-3589948 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | e-Med |
record_format | MEDLINE/PubMed |
spelling | pubmed-35899482014-06-13 Whole-body diffusion-weighted magnetic resonance imaging at 3 Tesla for early assessment of treatment response in non-Hodgkin lymphoma: a pilot study De Paepe, Katja Bevernage, Charlotte De Keyzer, Frederik Wolter, Pascal Gheysens, Olivier Janssens, Ann Oyen, Raymond Verhoef, Gregor Vandecaveye, Vincent Cancer Imaging Original Article Objective: To evaluate 3 Tesla (T) whole-body diffusion-weighted magnetic resonance imaging (WB DWI) for early treatment assessment in aggressive non-Hodgkin lymphoma (NHL). Methods: Fourteen patients with NHL treated with standard chemotherapy underwent 3-T WB DWI before and 2 and 4 weeks during treatment, using b-values of 0–1000 s/mm(2) from which the apparent diffusion coefficient (ADC) was calculated. Patient follow-up (average 20.3 months, range 15–23 months) was the reference standard. Volume and ADC changes between baseline and 2 weeks (Vratio(2w), ADCratio(2w)) and 4 weeks (Vratio(4w), ADCratio(4w)) of responding and non-responding lesions (lymph node and organ lesions) were compared using Mann–Whitney U tests. The per patient values of Vratio(N) and ADCratio(N) to predict progression-free survival were determined with a log-rank test. Results: Eight patients showed complete remission and 6 showed tumour progression. The ADCratio(2w) and ADCratio(4w) differed significantly in lesions showing tumour progression versus complete remission (ADCratio(2w) = 4 ± 21% versus 119 ± 68%; ADCratio(4w) = 18 ± 61% versus 155 ± 78%; both P < 0.0001); the Vratio(2w) and Vratio(4w) did not (P > 0.05). Per body region, the ADCratio(2w) showed a negative predictive value of 100% and positive predictive value of 86%. Per patient, the ADCratio(2w) and ADCratio(4w) correlated significantly with progression-free survival (P < 0.05). Conclusion: 3-T WB DWI with ADC quantification may enable early treatment assessment of aggressive NHL. e-Med 2013-03-05 /pmc/articles/PMC3589948/ /pubmed/23466737 http://dx.doi.org/10.1102/1470-7330.2013.0006 Text en © 2013 International Cancer Imaging Society |
spellingShingle | Original Article De Paepe, Katja Bevernage, Charlotte De Keyzer, Frederik Wolter, Pascal Gheysens, Olivier Janssens, Ann Oyen, Raymond Verhoef, Gregor Vandecaveye, Vincent Whole-body diffusion-weighted magnetic resonance imaging at 3 Tesla for early assessment of treatment response in non-Hodgkin lymphoma: a pilot study |
title | Whole-body diffusion-weighted magnetic resonance imaging at 3 Tesla for early assessment of treatment response in non-Hodgkin lymphoma: a pilot study |
title_full | Whole-body diffusion-weighted magnetic resonance imaging at 3 Tesla for early assessment of treatment response in non-Hodgkin lymphoma: a pilot study |
title_fullStr | Whole-body diffusion-weighted magnetic resonance imaging at 3 Tesla for early assessment of treatment response in non-Hodgkin lymphoma: a pilot study |
title_full_unstemmed | Whole-body diffusion-weighted magnetic resonance imaging at 3 Tesla for early assessment of treatment response in non-Hodgkin lymphoma: a pilot study |
title_short | Whole-body diffusion-weighted magnetic resonance imaging at 3 Tesla for early assessment of treatment response in non-Hodgkin lymphoma: a pilot study |
title_sort | whole-body diffusion-weighted magnetic resonance imaging at 3 tesla for early assessment of treatment response in non-hodgkin lymphoma: a pilot study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589948/ https://www.ncbi.nlm.nih.gov/pubmed/23466737 http://dx.doi.org/10.1102/1470-7330.2013.0006 |
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