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Whole-Genome Thermodynamic Analysis Reduces siRNA Off-Target Effects
Small interfering RNAs (siRNAs) are important tools for knocking down targeted genes, and have been widely applied to biological and biomedical research. To design siRNAs, two important aspects must be considered: the potency in knocking down target genes and the off-target effect on any nontarget g...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590146/ https://www.ncbi.nlm.nih.gov/pubmed/23484018 http://dx.doi.org/10.1371/journal.pone.0058326 |