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Enhanced Stimulus-Induced Gamma Activity in Humans during Propofol-Induced Sedation

Stimulus-induced gamma oscillations in the 30–80 Hz range have been implicated in a wide number of functions including visual processing, memory and attention. While occipital gamma-band oscillations can be pharmacologically modified in animal preparations, pharmacological modulation of stimulus-ind...

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Autores principales: Saxena, Neeraj, Muthukumaraswamy, Suresh D., Diukova, Ana, Singh, Krish, Hall, Judith, Wise, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590225/
https://www.ncbi.nlm.nih.gov/pubmed/23483920
http://dx.doi.org/10.1371/journal.pone.0057685
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author Saxena, Neeraj
Muthukumaraswamy, Suresh D.
Diukova, Ana
Singh, Krish
Hall, Judith
Wise, Richard
author_facet Saxena, Neeraj
Muthukumaraswamy, Suresh D.
Diukova, Ana
Singh, Krish
Hall, Judith
Wise, Richard
author_sort Saxena, Neeraj
collection PubMed
description Stimulus-induced gamma oscillations in the 30–80 Hz range have been implicated in a wide number of functions including visual processing, memory and attention. While occipital gamma-band oscillations can be pharmacologically modified in animal preparations, pharmacological modulation of stimulus-induced visual gamma oscillations has yet to be demonstrated in non-invasive human recordings. Here, in fifteen healthy humans volunteers, we probed the effects of the GABA(A) agonist and sedative propofol on stimulus-related gamma activity recorded with magnetoencephalography, using a simple visual grating stimulus designed to elicit gamma oscillations in the primary visual cortex. During propofol sedation as compared to the normal awake state, a significant 60% increase in stimulus-induced gamma amplitude was seen together with a 94% enhancement of stimulus-induced alpha suppression and a simultaneous reduction in the amplitude of the pattern-onset evoked response. These data demonstrate, that propofol-induced sedation is accompanied by increased stimulus-induced gamma activity providing a potential window into mechanisms of gamma-oscillation generation in humans.
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spelling pubmed-35902252013-03-12 Enhanced Stimulus-Induced Gamma Activity in Humans during Propofol-Induced Sedation Saxena, Neeraj Muthukumaraswamy, Suresh D. Diukova, Ana Singh, Krish Hall, Judith Wise, Richard PLoS One Research Article Stimulus-induced gamma oscillations in the 30–80 Hz range have been implicated in a wide number of functions including visual processing, memory and attention. While occipital gamma-band oscillations can be pharmacologically modified in animal preparations, pharmacological modulation of stimulus-induced visual gamma oscillations has yet to be demonstrated in non-invasive human recordings. Here, in fifteen healthy humans volunteers, we probed the effects of the GABA(A) agonist and sedative propofol on stimulus-related gamma activity recorded with magnetoencephalography, using a simple visual grating stimulus designed to elicit gamma oscillations in the primary visual cortex. During propofol sedation as compared to the normal awake state, a significant 60% increase in stimulus-induced gamma amplitude was seen together with a 94% enhancement of stimulus-induced alpha suppression and a simultaneous reduction in the amplitude of the pattern-onset evoked response. These data demonstrate, that propofol-induced sedation is accompanied by increased stimulus-induced gamma activity providing a potential window into mechanisms of gamma-oscillation generation in humans. Public Library of Science 2013-03-06 /pmc/articles/PMC3590225/ /pubmed/23483920 http://dx.doi.org/10.1371/journal.pone.0057685 Text en © 2013 Saxena et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Saxena, Neeraj
Muthukumaraswamy, Suresh D.
Diukova, Ana
Singh, Krish
Hall, Judith
Wise, Richard
Enhanced Stimulus-Induced Gamma Activity in Humans during Propofol-Induced Sedation
title Enhanced Stimulus-Induced Gamma Activity in Humans during Propofol-Induced Sedation
title_full Enhanced Stimulus-Induced Gamma Activity in Humans during Propofol-Induced Sedation
title_fullStr Enhanced Stimulus-Induced Gamma Activity in Humans during Propofol-Induced Sedation
title_full_unstemmed Enhanced Stimulus-Induced Gamma Activity in Humans during Propofol-Induced Sedation
title_short Enhanced Stimulus-Induced Gamma Activity in Humans during Propofol-Induced Sedation
title_sort enhanced stimulus-induced gamma activity in humans during propofol-induced sedation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590225/
https://www.ncbi.nlm.nih.gov/pubmed/23483920
http://dx.doi.org/10.1371/journal.pone.0057685
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