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Enhanced Stimulus-Induced Gamma Activity in Humans during Propofol-Induced Sedation
Stimulus-induced gamma oscillations in the 30–80 Hz range have been implicated in a wide number of functions including visual processing, memory and attention. While occipital gamma-band oscillations can be pharmacologically modified in animal preparations, pharmacological modulation of stimulus-ind...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590225/ https://www.ncbi.nlm.nih.gov/pubmed/23483920 http://dx.doi.org/10.1371/journal.pone.0057685 |
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author | Saxena, Neeraj Muthukumaraswamy, Suresh D. Diukova, Ana Singh, Krish Hall, Judith Wise, Richard |
author_facet | Saxena, Neeraj Muthukumaraswamy, Suresh D. Diukova, Ana Singh, Krish Hall, Judith Wise, Richard |
author_sort | Saxena, Neeraj |
collection | PubMed |
description | Stimulus-induced gamma oscillations in the 30–80 Hz range have been implicated in a wide number of functions including visual processing, memory and attention. While occipital gamma-band oscillations can be pharmacologically modified in animal preparations, pharmacological modulation of stimulus-induced visual gamma oscillations has yet to be demonstrated in non-invasive human recordings. Here, in fifteen healthy humans volunteers, we probed the effects of the GABA(A) agonist and sedative propofol on stimulus-related gamma activity recorded with magnetoencephalography, using a simple visual grating stimulus designed to elicit gamma oscillations in the primary visual cortex. During propofol sedation as compared to the normal awake state, a significant 60% increase in stimulus-induced gamma amplitude was seen together with a 94% enhancement of stimulus-induced alpha suppression and a simultaneous reduction in the amplitude of the pattern-onset evoked response. These data demonstrate, that propofol-induced sedation is accompanied by increased stimulus-induced gamma activity providing a potential window into mechanisms of gamma-oscillation generation in humans. |
format | Online Article Text |
id | pubmed-3590225 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-35902252013-03-12 Enhanced Stimulus-Induced Gamma Activity in Humans during Propofol-Induced Sedation Saxena, Neeraj Muthukumaraswamy, Suresh D. Diukova, Ana Singh, Krish Hall, Judith Wise, Richard PLoS One Research Article Stimulus-induced gamma oscillations in the 30–80 Hz range have been implicated in a wide number of functions including visual processing, memory and attention. While occipital gamma-band oscillations can be pharmacologically modified in animal preparations, pharmacological modulation of stimulus-induced visual gamma oscillations has yet to be demonstrated in non-invasive human recordings. Here, in fifteen healthy humans volunteers, we probed the effects of the GABA(A) agonist and sedative propofol on stimulus-related gamma activity recorded with magnetoencephalography, using a simple visual grating stimulus designed to elicit gamma oscillations in the primary visual cortex. During propofol sedation as compared to the normal awake state, a significant 60% increase in stimulus-induced gamma amplitude was seen together with a 94% enhancement of stimulus-induced alpha suppression and a simultaneous reduction in the amplitude of the pattern-onset evoked response. These data demonstrate, that propofol-induced sedation is accompanied by increased stimulus-induced gamma activity providing a potential window into mechanisms of gamma-oscillation generation in humans. Public Library of Science 2013-03-06 /pmc/articles/PMC3590225/ /pubmed/23483920 http://dx.doi.org/10.1371/journal.pone.0057685 Text en © 2013 Saxena et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Saxena, Neeraj Muthukumaraswamy, Suresh D. Diukova, Ana Singh, Krish Hall, Judith Wise, Richard Enhanced Stimulus-Induced Gamma Activity in Humans during Propofol-Induced Sedation |
title | Enhanced Stimulus-Induced Gamma Activity in Humans during Propofol-Induced Sedation |
title_full | Enhanced Stimulus-Induced Gamma Activity in Humans during Propofol-Induced Sedation |
title_fullStr | Enhanced Stimulus-Induced Gamma Activity in Humans during Propofol-Induced Sedation |
title_full_unstemmed | Enhanced Stimulus-Induced Gamma Activity in Humans during Propofol-Induced Sedation |
title_short | Enhanced Stimulus-Induced Gamma Activity in Humans during Propofol-Induced Sedation |
title_sort | enhanced stimulus-induced gamma activity in humans during propofol-induced sedation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590225/ https://www.ncbi.nlm.nih.gov/pubmed/23483920 http://dx.doi.org/10.1371/journal.pone.0057685 |
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