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A small organic compound enhances the religation reaction of human topoisomerase I and identifies crucial elements for the religation mechanism

The different steps of the human Top1 (topoisomerase I) catalytic cycle have been analysed in the presence of a pentacyclic-diquinoid synthetic compound. The experiments indicate that it efficiently inhibits the cleavage step of the enzyme reaction, fitting well into the catalytic site. Surprisingly...

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Detalles Bibliográficos
Autores principales:	Arnò, Barbara, Coletta, Andrea, Tesauro, Cinzia, Zuccaro, Laura, Fiorani, Paola, Lentini, Sara, Galloni, Pierluca, Conte, Valeria, Floris, Barbara, Desideri, Alessandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2013
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590572/ https://www.ncbi.nlm.nih.gov/pubmed/23368812 http://dx.doi.org/10.1042/BSR20120118

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