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Heparin and Carboxymethylchitosan Metal Nanoparticles: An Evaluation of Their Cytotoxicity
In the search for noninvasive diagnostic techniques and new therapies, “nanosystems”, which are capable of binding and targeting bioactive molecules, are becoming increasingly important. In this context, biocompatible coatings are gaining interest, not only for their biological effects but also beca...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590581/ https://www.ncbi.nlm.nih.gov/pubmed/23509708 http://dx.doi.org/10.1155/2013/314091 |
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author | Bava, Adriana Cappellini, Francesca Pedretti, Elisa Rossi, Federica Caruso, Enrico Vismara, Elena Chiriva-Internati, Maurizio Bernardini, Giovanni Gornati, Rosalba |
author_facet | Bava, Adriana Cappellini, Francesca Pedretti, Elisa Rossi, Federica Caruso, Enrico Vismara, Elena Chiriva-Internati, Maurizio Bernardini, Giovanni Gornati, Rosalba |
author_sort | Bava, Adriana |
collection | PubMed |
description | In the search for noninvasive diagnostic techniques and new therapies, “nanosystems”, which are capable of binding and targeting bioactive molecules, are becoming increasingly important. In this context, biocompatible coatings are gaining interest, not only for their biological effects but also because they are considered capable to mask nanoparticle toxicity. In this work, we have compared the toxicity of nanoparticles coated with heparin and carboxymethylchitosan in the SKOV-3 cell line. Our results indicate that heparin and carboxymethylchitosan coatings do not guarantee the decrease of nanoparticle intrinsic toxicity which is often envisaged. Nonetheless, these coatings provide the opportunity for further functionalization with a variety of biomolecules for their use in theranostics. |
format | Online Article Text |
id | pubmed-3590581 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-35905812013-03-18 Heparin and Carboxymethylchitosan Metal Nanoparticles: An Evaluation of Their Cytotoxicity Bava, Adriana Cappellini, Francesca Pedretti, Elisa Rossi, Federica Caruso, Enrico Vismara, Elena Chiriva-Internati, Maurizio Bernardini, Giovanni Gornati, Rosalba Biomed Res Int Research Article In the search for noninvasive diagnostic techniques and new therapies, “nanosystems”, which are capable of binding and targeting bioactive molecules, are becoming increasingly important. In this context, biocompatible coatings are gaining interest, not only for their biological effects but also because they are considered capable to mask nanoparticle toxicity. In this work, we have compared the toxicity of nanoparticles coated with heparin and carboxymethylchitosan in the SKOV-3 cell line. Our results indicate that heparin and carboxymethylchitosan coatings do not guarantee the decrease of nanoparticle intrinsic toxicity which is often envisaged. Nonetheless, these coatings provide the opportunity for further functionalization with a variety of biomolecules for their use in theranostics. Hindawi Publishing Corporation 2013 2013-02-18 /pmc/articles/PMC3590581/ /pubmed/23509708 http://dx.doi.org/10.1155/2013/314091 Text en Copyright © 2013 Adriana Bava et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Bava, Adriana Cappellini, Francesca Pedretti, Elisa Rossi, Federica Caruso, Enrico Vismara, Elena Chiriva-Internati, Maurizio Bernardini, Giovanni Gornati, Rosalba Heparin and Carboxymethylchitosan Metal Nanoparticles: An Evaluation of Their Cytotoxicity |
title | Heparin and Carboxymethylchitosan Metal Nanoparticles: An Evaluation of Their Cytotoxicity |
title_full | Heparin and Carboxymethylchitosan Metal Nanoparticles: An Evaluation of Their Cytotoxicity |
title_fullStr | Heparin and Carboxymethylchitosan Metal Nanoparticles: An Evaluation of Their Cytotoxicity |
title_full_unstemmed | Heparin and Carboxymethylchitosan Metal Nanoparticles: An Evaluation of Their Cytotoxicity |
title_short | Heparin and Carboxymethylchitosan Metal Nanoparticles: An Evaluation of Their Cytotoxicity |
title_sort | heparin and carboxymethylchitosan metal nanoparticles: an evaluation of their cytotoxicity |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590581/ https://www.ncbi.nlm.nih.gov/pubmed/23509708 http://dx.doi.org/10.1155/2013/314091 |
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