Cargando…

Heparin and Carboxymethylchitosan Metal Nanoparticles: An Evaluation of Their Cytotoxicity

In the search for noninvasive diagnostic techniques and new therapies, “nanosystems”, which are capable of binding and targeting bioactive molecules, are becoming increasingly important. In this context, biocompatible coatings are gaining interest, not only for their biological effects but also beca...

Descripción completa

Detalles Bibliográficos
Autores principales: Bava, Adriana, Cappellini, Francesca, Pedretti, Elisa, Rossi, Federica, Caruso, Enrico, Vismara, Elena, Chiriva-Internati, Maurizio, Bernardini, Giovanni, Gornati, Rosalba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590581/
https://www.ncbi.nlm.nih.gov/pubmed/23509708
http://dx.doi.org/10.1155/2013/314091
_version_ 1782261888391839744
author Bava, Adriana
Cappellini, Francesca
Pedretti, Elisa
Rossi, Federica
Caruso, Enrico
Vismara, Elena
Chiriva-Internati, Maurizio
Bernardini, Giovanni
Gornati, Rosalba
author_facet Bava, Adriana
Cappellini, Francesca
Pedretti, Elisa
Rossi, Federica
Caruso, Enrico
Vismara, Elena
Chiriva-Internati, Maurizio
Bernardini, Giovanni
Gornati, Rosalba
author_sort Bava, Adriana
collection PubMed
description In the search for noninvasive diagnostic techniques and new therapies, “nanosystems”, which are capable of binding and targeting bioactive molecules, are becoming increasingly important. In this context, biocompatible coatings are gaining interest, not only for their biological effects but also because they are considered capable to mask nanoparticle toxicity. In this work, we have compared the toxicity of nanoparticles coated with heparin and carboxymethylchitosan in the SKOV-3 cell line. Our results indicate that heparin and carboxymethylchitosan coatings do not guarantee the decrease of nanoparticle intrinsic toxicity which is often envisaged. Nonetheless, these coatings provide the opportunity for further functionalization with a variety of biomolecules for their use in theranostics.
format Online
Article
Text
id pubmed-3590581
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-35905812013-03-18 Heparin and Carboxymethylchitosan Metal Nanoparticles: An Evaluation of Their Cytotoxicity Bava, Adriana Cappellini, Francesca Pedretti, Elisa Rossi, Federica Caruso, Enrico Vismara, Elena Chiriva-Internati, Maurizio Bernardini, Giovanni Gornati, Rosalba Biomed Res Int Research Article In the search for noninvasive diagnostic techniques and new therapies, “nanosystems”, which are capable of binding and targeting bioactive molecules, are becoming increasingly important. In this context, biocompatible coatings are gaining interest, not only for their biological effects but also because they are considered capable to mask nanoparticle toxicity. In this work, we have compared the toxicity of nanoparticles coated with heparin and carboxymethylchitosan in the SKOV-3 cell line. Our results indicate that heparin and carboxymethylchitosan coatings do not guarantee the decrease of nanoparticle intrinsic toxicity which is often envisaged. Nonetheless, these coatings provide the opportunity for further functionalization with a variety of biomolecules for their use in theranostics. Hindawi Publishing Corporation 2013 2013-02-18 /pmc/articles/PMC3590581/ /pubmed/23509708 http://dx.doi.org/10.1155/2013/314091 Text en Copyright © 2013 Adriana Bava et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bava, Adriana
Cappellini, Francesca
Pedretti, Elisa
Rossi, Federica
Caruso, Enrico
Vismara, Elena
Chiriva-Internati, Maurizio
Bernardini, Giovanni
Gornati, Rosalba
Heparin and Carboxymethylchitosan Metal Nanoparticles: An Evaluation of Their Cytotoxicity
title Heparin and Carboxymethylchitosan Metal Nanoparticles: An Evaluation of Their Cytotoxicity
title_full Heparin and Carboxymethylchitosan Metal Nanoparticles: An Evaluation of Their Cytotoxicity
title_fullStr Heparin and Carboxymethylchitosan Metal Nanoparticles: An Evaluation of Their Cytotoxicity
title_full_unstemmed Heparin and Carboxymethylchitosan Metal Nanoparticles: An Evaluation of Their Cytotoxicity
title_short Heparin and Carboxymethylchitosan Metal Nanoparticles: An Evaluation of Their Cytotoxicity
title_sort heparin and carboxymethylchitosan metal nanoparticles: an evaluation of their cytotoxicity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590581/
https://www.ncbi.nlm.nih.gov/pubmed/23509708
http://dx.doi.org/10.1155/2013/314091
work_keys_str_mv AT bavaadriana heparinandcarboxymethylchitosanmetalnanoparticlesanevaluationoftheircytotoxicity
AT cappellinifrancesca heparinandcarboxymethylchitosanmetalnanoparticlesanevaluationoftheircytotoxicity
AT pedrettielisa heparinandcarboxymethylchitosanmetalnanoparticlesanevaluationoftheircytotoxicity
AT rossifederica heparinandcarboxymethylchitosanmetalnanoparticlesanevaluationoftheircytotoxicity
AT carusoenrico heparinandcarboxymethylchitosanmetalnanoparticlesanevaluationoftheircytotoxicity
AT vismaraelena heparinandcarboxymethylchitosanmetalnanoparticlesanevaluationoftheircytotoxicity
AT chirivainternatimaurizio heparinandcarboxymethylchitosanmetalnanoparticlesanevaluationoftheircytotoxicity
AT bernardinigiovanni heparinandcarboxymethylchitosanmetalnanoparticlesanevaluationoftheircytotoxicity
AT gornatirosalba heparinandcarboxymethylchitosanmetalnanoparticlesanevaluationoftheircytotoxicity