Epidemiological Determinants of Successful Vaccine Development

Epidemiological determinants of successful vaccine development were explored using measurable biological variables including antigenic stability and requirement of T-cell immunity. Employing a logistic regression model, we demonstrate that a high affinity with blood and immune cells and pathogen int...

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Detalles Bibliográficos
Autores principales: Nishiura, Hiroshi, Mizumoto, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2013
Materias:
Short Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590596/
https://www.ncbi.nlm.nih.gov/pubmed/23471119
http://dx.doi.org/10.7150/ijms.5689
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author Nishiura, Hiroshi
Mizumoto, Kenji
author_facet Nishiura, Hiroshi
Mizumoto, Kenji
author_sort Nishiura, Hiroshi
collection PubMed
description Epidemiological determinants of successful vaccine development were explored using measurable biological variables including antigenic stability and requirement of T-cell immunity. Employing a logistic regression model, we demonstrate that a high affinity with blood and immune cells and pathogen interactions (e.g. interference) would be the risk factors of failure for vaccine development.
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spelling pubmed-35905962013-03-07 Epidemiological Determinants of Successful Vaccine Development Nishiura, Hiroshi Mizumoto, Kenji Int J Med Sci Short Research Communication Epidemiological determinants of successful vaccine development were explored using measurable biological variables including antigenic stability and requirement of T-cell immunity. Employing a logistic regression model, we demonstrate that a high affinity with blood and immune cells and pathogen interactions (e.g. interference) would be the risk factors of failure for vaccine development. Ivyspring International Publisher 2013-02-21 /pmc/articles/PMC3590596/ /pubmed/23471119 http://dx.doi.org/10.7150/ijms.5689 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Short Research Communication
Nishiura, Hiroshi
Mizumoto, Kenji
Epidemiological Determinants of Successful Vaccine Development
title Epidemiological Determinants of Successful Vaccine Development
title_full Epidemiological Determinants of Successful Vaccine Development
title_fullStr Epidemiological Determinants of Successful Vaccine Development
title_full_unstemmed Epidemiological Determinants of Successful Vaccine Development
title_short Epidemiological Determinants of Successful Vaccine Development
title_sort epidemiological determinants of successful vaccine development
topic Short Research Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590596/
https://www.ncbi.nlm.nih.gov/pubmed/23471119
http://dx.doi.org/10.7150/ijms.5689
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