Cargando…

Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology

Current drug development in oncology is non-selective as it typically focuses on pathways essential for the survival of all dividing cells. The unique metabolic profile of cancer, which is characterized by increased glycolysis and suppressed mitochondrial glucose oxidation (GO) provides cancer cells...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sutendra, Gopinath, Michelakis, Evangelos D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2013
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590642/ https://www.ncbi.nlm.nih.gov/pubmed/23471124 http://dx.doi.org/10.3389/fonc.2013.00038

Ejemplares similares

Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
por: Jeoung, Nam Ho
Publicado: (2015)

Overexpression of Pyruvate Dehydrogenase Kinase-3 Predicts Poor Prognosis in Urothelial Carcinoma
por: Kuo, Yu-Hsuan, et al.
Publicado: (2021)

Pyruvate Dehydrogenase Kinase as a Potential Therapeutic Target for Malignant Gliomas
por: Jha, Mithilesh Kumar, et al.
Publicado: (2013)

Posttranslational Modifications of Pyruvate Kinase M2: Tweaks that Benefit Cancer
por: Prakasam, Gopinath, et al.
Publicado: (2018)

Expression of pyruvate dehydrogenase kinase-1 in gastric cancer as a potential therapeutic target
por: HUR, HOON, et al.
Publicado: (2012)

Transcriptional Regulation of Pyruvate Dehydrogenase Kinase
por: Jeong, Ji Yun, et al.
Publicado: (2012)

Pioglitazone inhibits HIF-1α-dependent angiogenesis in rats by paracrine and direct effects on endothelial cells
por: Dromparis, Peter, et al.
Publicado: (2014)

Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis
por: Ferrarini, Mariana Galvão, et al.
Publicado: (2021)

Heterogeneous Expression and Subcellular Localization of Pyruvate Dehydrogenase Complex in Prostate Cancer
por: Nunes-Xavier, Caroline E., et al.
Publicado: (2022)

The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
por: Lee, In-Kyu
Publicado: (2014)

A Similar Metabolic Profile Between the Failing Myocardium and Tumor Could Provide Alternative Therapeutic Targets in Chemotherapy-Induced Cardiotoxicity
por: Saleme, Bruno, et al.
Publicado: (2018)

p53‐Mediated Repression of the PGC1A (PPARG Coactivator 1α) and APLNR (Apelin Receptor) Signaling Pathways Limits Fatty Acid Oxidation Energetics: Implications for Cardio‐oncology
por: Saleme, Bruno, et al.
Publicado: (2020)

The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility
por: Zhang, Shuai, et al.
Publicado: (2014)

Refining the Role of Pyruvate Dehydrogenase Kinases in Glioblastoma Development
por: Larrieu, Claire M., et al.
Publicado: (2022)

Asp295 Stabilizes the Active-Site Loop Structure of Pyruvate Dehydrogenase, Facilitating Phosphorylation of Ser292 by Pyruvate Dehydrogenase-Kinase
por: Hirani, Tripty A., et al.
Publicado: (2011)

Targeting Endothelial Cell Metabolism by Inhibition of Pyruvate Dehydrogenase Kinase and Glutaminase-1
por: Schoonjans, Céline A., et al.
Publicado: (2020)

Overexpression of pyruvate dehydrogenase kinase 1 in retinoblastoma: A potential therapeutic opportunity for targeting vitreous seeds and hypoxic regions
por: Sradhanjali, Swatishree, et al.
Publicado: (2017)

Mutant Isocitrate Dehydrogenase Inhibitors as Targeted Cancer Therapeutics
por: Golub, Danielle, et al.
Publicado: (2019)

Pyruvate dehydrogenase kinase regulates hepatitis C virus replication
por: Jung, Gwon-Soo, et al.
Publicado: (2016)

Pyruvate dehydrogenase kinases (PDKs): an overview toward clinical applications
por: Wang, Xiuxiu, et al.
Publicado: (2021)

Targeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target?
por: Zhang, Wen, et al.
Publicado: (2015)

Pyruvate Dehydrogenase Complex and Glucose Oxidation as a Therapeutic Target in Diabetic Heart Disease
por: Tabatabaei Dakhili, Seyed Amirhossein, et al.
Publicado: (2023)

Pyruvate dehydrogenase complex and lactate dehydrogenase are targets for therapy of acute liver failure
por: Ferriero, Rosa, et al.
Publicado: (2018)

Role of Pyruvate Dehydrogenase Kinase 4 in Regulation of Blood Glucose Levels
por: Jeoung, Nam Ho, et al.
Publicado: (2010)

Computational Study on New Natural Compound Inhibitors of Pyruvate Dehydrogenase Kinases
por: Zhou, Xiaoli, et al.
Publicado: (2016)

Mechanisms of Vascular Calcification: The Pivotal Role of Pyruvate Dehydrogenase Kinase 4
por: Leem, Jaechan, et al.
Publicado: (2016)

Global view of cognate kinase activation by the human pyruvate dehydrogenase complex
por: Guevara, Elena L., et al.
Publicado: (2017)

Reversing tozasertib resistance in glioma through inhibition of pyruvate dehydrogenase kinases
por: Jane, Esther P., et al.
Publicado: (2021)

Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis
por: Zahra, Kulsoom, et al.
Publicado: (2020)

A novel null mutation in the pyruvate dehydrogenase phosphatase catalytic subunit gene (PDP1) causing pyruvate dehydrogenase complex deficiency
por: Bedoyan, Jirair K., et al.
Publicado: (2019)

Loss of metabolic flexibility as a result of overexpression of pyruvate dehydrogenase kinases in muscle, liver and the immune system: Therapeutic targets in metabolic diseases
por: Jeon, Jae‐Han, et al.
Publicado: (2020)

Association of Phosphorylated Pyruvate Dehydrogenase with Pyruvate Kinase M2 Promotes PKM2 Stability in Response to Insulin
por: Hossain, Abu Jubayer, et al.
Publicado: (2023)

CD44 Glycosylation as a Therapeutic Target in Oncology
por: Liao, Chengcheng, et al.
Publicado: (2022)

Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism
por: Park, Sungmi, et al.
Publicado: (2018)

Dimethylaminomicheliolide (DMAMCL) Suppresses the Proliferation of Glioblastoma Cells via Targeting Pyruvate Kinase 2 (PKM2) and Rewiring Aerobic Glycolysis
por: Guo, Jianshuang, et al.
Publicado: (2019)

Pyruvate dehydrogenase kinase is a negative regulator of interleukin-10 production in macrophages
por: Na, Yi Rang, et al.
Publicado: (2020)

Molecular interaction studies on ellagic acid for its anticancer potential targeting pyruvate dehydrogenase kinase 3
por: Dahiya, Rashmi, et al.
Publicado: (2019)

Pyruvate Dehydrogenase Kinase 4: Regulation by Thiazolidinediones and Implication in Glyceroneogenesis in Adipose Tissue
por: Cadoudal, Thomas, et al.
Publicado: (2008)

The Aspergillus nidulans Pyruvate Dehydrogenase Kinases Are Essential To Integrate Carbon Source Metabolism
por: Ries, Laure Nicolas Annick, et al.
Publicado: (2018)

Fasting and Glucagon Stimulate Gene Expression of Pyruvate Dehydrogenase Kinase 4 in Chickens
por: Honda, Kazuhisa, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_c3n33c233eres0jj16vmfpqrbi